Abstract | BACKGROUND: The progressive accumulation of misfolded and aggregated proteins in neurons is an accepted mechanism in aging. Overproduction of reactive oxygen species (ROS), referred to as oxidative stress, is currently believed to play a pivotal role in this process. Lipofuscin as a histological index of aging results from cross-links between oxidized proteins and lipids. Therefore, to attenuate lipofuscin formation, it would be logical to use exogenous natural or synthetic antioxidants. Yakuchinone B (1-[4'-hydroxy-3'-methoxyphenyl]-7-phenylhept-1-en-3-one) is a component of Alpinia oxyphylla seeds with established antioxidant activity. METHODS: RESULTS: Our results indicated that derivatives especially JC4, JC5 and JC6 decreased the extent of apoptosis and ROS level, while they increased the activities of SOD and CAT in drug-pretreated cells as compared to H2O2-treated cells. A clear relationship between the structure and antioxidant activities of these compounds was established. In addition, JC4, JC5 and JC6 were capable of down-regulating the formation of MDA and lipofuscin. CONCLUSION:
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Authors | Samaneh Bayati, Razieh Yazdanparast |
Journal | Iranian biomedical journal
(Iran Biomed J)
Vol. 15
Issue 4
Pg. 134-42
( 2011)
ISSN: 2008-823X [Electronic] Iran |
PMID | 22395138
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antioxidants
- Diarylheptanoids
- Free Radical Scavengers
- Lipofuscin
- Protective Agents
- yakuchinone B
- Chalcone
- Hydrogen Peroxide
- Catalase
- Superoxide Dismutase
- Acid Phosphatase
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Topics |
- Acid Phosphatase
(metabolism)
- Antioxidants
(pharmacology)
- Apoptosis
(drug effects)
- Catalase
(metabolism)
- Cell Line, Tumor
- Cell Survival
(drug effects)
- Chalcone
(chemistry)
- Diarylheptanoids
(chemistry, pharmacology)
- Free Radical Scavengers
(pharmacology)
- Humans
- Hydrogen Peroxide
(pharmacology)
- Intracellular Space
(drug effects, enzymology)
- Lipid Peroxidation
(drug effects)
- Lipofuscin
(metabolism)
- Neuroblastoma
(enzymology, pathology)
- Protective Agents
(pharmacology)
- Superoxide Dismutase
(metabolism)
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