Effect of genetic polymorphism of UCP2-866 G/A on repaglinide response in Chinese patients with type 2 diabetes.

Abstract

The aim of the present study was to evaluate the impact of the UCP2-866 G/A polymorphism on the efficacy of repaglinide in treating patients with diabetes mellitus type 2 (T2DM). 370 patients with T2DM and 166 healthy volunteers were enrolled to identify UCP2-866 G/A genotypes. 16 patients with GG genotype, 14 with GA genotype and 11 with AA genotype of UCP2-866 G/A underwent an 8-week repaglinide treatment regimen. There were no differences in allele frequency of UCP2-866 G/A between T2DM patients and control subjects. The patient with AA genotype of UCP2-866 G/A had higher levels of fasting plasma glucose (FPG), 30-min and 2-h postload plasma glucose, glycated haemoglobin (HbA1c), and lower concentrations of 30-min and 2-h postload plasma insulin, homeostasis model assessment of beta cell function (HOMA-beta), deltaI30/deltaG30 compared with GG genotype. After repaglinide treatment for 8 consecutive weeks, we found that A allele carriers of UCP2 in the T2DM patients had smaller decrease in FPG (P < 0.05) and HbA1c (P < 0.05), and smaller increase in 30-min postload plasma insulin (P < 0.01) compared with GG genotypes. We demonstrated that UCP2-866 G/A polymorphism is associated with the therapeutic efficacy of repaglinide in Chinese T2DM patients.

• Authors: Shan Wang, Yan-Mei Se, Zhao-Qian Liu, Ming-Xiang Lei, Hao-BoYang, Zhi-Xiang Sun, Sheng-Dan Nie, Xiao-min Zeng, Jing Wu
• Journal: Die Pharmazie (Pharmazie) Vol. 67 Issue 1 Pg. 74-9 (Jan 2012) ISSN: 0031-7144 [Print] Germany
• PMID: 22393835 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Blood Glucose
• Carbamates
• DNA Primers
• Hypoglycemic Agents
• Insulin
• Ion Channels
• Mitochondrial Proteins
• Piperidines
• UCP2 protein, human
• Uncoupling Protein 2
• repaglinide

Topics

• Adult
• Aged
• Alleles
• Asian People (genetics)
• Blood Glucose (metabolism)
• Carbamates (pharmacology)
• DNA Primers
• Diabetes Mellitus, Type 2 (drug therapy, genetics)
• Female
• Genotype
• Humans
• Hypoglycemic Agents (pharmacology)
• Insulin (blood)
• Insulin-Secreting Cells (physiology)
• Ion Channels (genetics)
• Male
• Middle Aged
• Mitochondrial Proteins (genetics)
• Pancreatic Function Tests
• Piperidines (pharmacology)
• Polymerase Chain Reaction
• Uncoupling Protein 2