[Effect of artesunate transdermal preparation on Plasmodium cynomolgi].

Abstract

Artensunate transdermal preparation at 5, 10, or 15 mg/kg, bid, for 3 days applied locally on the shaved skin of the back of monkeys showed reliable therapeutic effects on Plasmodium cynomolgi, but recrudescence of the parasites was not controlled. If some azone was added in the artesunate transdermal preparation at the dosage of 5 mg/kg, bid, for 3 days, the parasitemia of Plasmodium cynomolgi could be cleared and recrudescence prevented, thus, the antimalarial effects was enhanced.

• Authors: W Y Xuan, Y Zhao, A Y Li, P S Xie, X Liu
• Journal: Yao xue xue bao = Acta pharmaceutica Sinica (Yao Xue Xue Bao) Vol. 25 Issue 3 Pg. 220-2 ( 1990) ISSN: 0513-4870 [Print] China
• PMID: 2239338 (Publication Type: Journal Article)

Chemical References

• Antimalarials
• Artemisinins
• Azepines
• Sesquiterpenes
• laurocapram
• Artesunate

Topics

• Administration, Cutaneous
• Animals
• Antimalarials (administration & dosage, therapeutic use)
• Artemisinins
• Artesunate
• Azepines (administration & dosage)
• Drug Synergism
• Macaca mulatta
• Malaria (drug therapy)
• Male
• Plasmodium
• Sesquiterpenes (administration & dosage, therapeutic use)