Abstract | BACKGROUND: E26 transformation-specific sequence-1 (ETS1) transcription factor plays important roles in both carcinogenesis and the progression of a wide range of malignancies. Aberrant ETS1 expression correlates with aggressive tumor behavior and a poorer prognosis in patients with various malignancies. The aim of the current study was to evaluate the efficacy of a drug delivery system utilizing gambogic acid-loaded magnetic Fe(3)O(4) nanoparticles (GA-MNP-Fe(3)O(4)) on the suppression of ETS1-mediated cell proliferation and migration in Panc-1 pancreatic cancer cells. METHODS: RESULTS: CONCLUSION: Our novel finding reaffirmed the significance of ETS1 in the treatment of pancreatic cancer, and application of GA-MNP-Fe(3)O(4) nanoparticles targeting ETS1 should be considered as a promising contribution for better pancreatic cancer care.
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Authors | Cailian Wang, Haijun Zhang, Yan Chen, Fangfang Shi, Baoan Chen |
Journal | International journal of nanomedicine
(Int J Nanomedicine)
Vol. 7
Pg. 781-7
( 2012)
ISSN: 1178-2013 [Electronic] New Zealand |
PMID | 22393285
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Carriers
- ETS1 protein, human
- Magnetite Nanoparticles
- Proto-Oncogene Protein c-ets-1
- Xanthones
- gambogic acid
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Topics |
- Cell Growth Processes
(drug effects)
- Cell Line, Tumor
- Cell Movement
(drug effects)
- Cell Survival
(drug effects)
- Drug Carriers
(chemistry, pharmacology)
- Humans
- Magnetite Nanoparticles
(chemistry)
- Pancreatic Neoplasms
(drug therapy, metabolism, pathology)
- Proto-Oncogene Protein c-ets-1
(antagonists & inhibitors)
- Xanthones
(chemistry, pharmacology)
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