Very early recurrence of anti-Phospholipase A2 receptor-positive membranous nephropathy after transplantation.

Abstract

Membranous nephropathy is a common cause of adult nephrotic syndrome, with recent evidence suggesting that 70% of idiopathic disease is associated with anti-Phospholipase A(2) receptor autoantibodies. We describe a 63-year-old man with membranous nephropathy who underwent a kidney transplant and developed recurrent membranous nephropathy with fine granular co-localization of Phospholipase A(2) receptor and IgG evident on transplant biopsy on day 6 and elevated circulating levels of serum anti-Phospholipase A(2) receptor autoantibody that declined over time in conjunction with improvement in the serum creatinine and urinary protein. This is a very early case of Phospholipase A(2) receptor-associated recurrent membranous nephropathy with circulating anti-Phospholipase A(2) receptor autoantibody, which supports the emerging evidence that idiopathic membranous nephropathy is an autoimmune disease.

• Authors: C D Blosser, R Ayalon, R Nair, C Thomas, L H Beck Jr
• Journal: American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons (Am J Transplant) Vol. 12 Issue 6 Pg. 1637-42 (Jun 2012) ISSN: 1600-6143 [Electronic] United States
• PMID: 22390840 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © Copyright 2011 The American Society of Transplantation and the American Society of Transplant Surgeons.

Chemical References

• Autoantibodies
• Receptors, Phospholipase A2

Topics

• Autoantibodies (immunology)
• Glomerulonephritis, Membranous (immunology, pathology, surgery)
• Humans
• Kidney Transplantation
• Male
• Middle Aged
• Receptors, Phospholipase A2 (immunology)
• Recurrence