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Longitudinal ¹H MRS assessment of the thalamus in a Coriaria lactone-induced rhesus monkey status epilepticus model.

Abstract
Neurophysiological, biochemical and anatomical evidence implicates the thalamus as playing a role in epileptic seizures. Until recently, however, longitudinal characterization of in vivo thalamus dynamics had not been reported. In this study, we investigated the metabolism in the thalamus to identify the changes that occur following Coriaria lactone (CL)-induced status epilepticus (SE) and to observe whether the epileptiform discharges could present a difference between the left and right thalami. Five rhesus monkeys underwent whole-brain MRI and single-voxel MRS on a Siemens Trio Tim 3-T MR scanner with a 12-channel head coil. Spectra were processed using LCModel. Scans were performed in five animals before SE and at 1, 7, 21 and 42  days after the onset of SE. Statistical analysis of the data obtained demonstrated no significant difference in the bilateral thalamus of healthy macaques. Our MRS data showed symmetrical distributions of N-acetylaspartate in the right and left thalami after SE (p = 0.003). In addition, this longitudinal study demonstrated elevated glutamate/glutamine (p < 0.05) and reduced myo-inositol (p < 0.05) in the bilateral thalamus 1  day after SE, and all metabolites approached their baseline levels by the fifth scan. Our results demonstrate that metabolic changes occur in the thalamus during CL-induced SE in rhesus monkeys. The various metabolic changes may indicate that the left thalamus is more vulnerable to epileptic strike.
AuthorsXiao-Yun Zhang, Zhi-Yong Yang, Jin-Mei Li, Hong-Xia Li, Li Wang, Qi-Yong Gong, Dong Zhou
JournalNMR in biomedicine (NMR Biomed) Vol. 25 Issue 10 Pg. 1196-201 (Oct 2012) ISSN: 1099-1492 [Electronic] England
PMID22389048 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 John Wiley & Sons, Ltd.
Chemical References
  • Lactones
  • Protons
  • Glutamic Acid
  • Inositol
  • coriaria lactone
  • Creatinine
Topics
  • Animals
  • Creatinine (metabolism)
  • Disease Models, Animal
  • Glutamic Acid (metabolism)
  • Inositol (metabolism)
  • Lactones
  • Macaca mulatta
  • Magnetic Resonance Spectroscopy (methods)
  • Metabolome
  • Protons
  • Status Epilepticus (metabolism, pathology)
  • Thalamus (metabolism)
  • Time Factors

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