Abstract |
Resistance to thyroid hormone (RTH) is a rare, predominantly inherited syndrome that involves impaired tissue responsiveness to thyroid hormones. We describe the perioperative management of a patient with RTH who underwent total thyroidectomy. Although surgery performed under general anesthesia was uneventful, after the surgery the patient developed difficult-to-treat hypocalcemia that lasted until postoperative day 4. Moreover, thyroid function even after discharge remained unstable despite replacement therapy. We suggest that the parathyroid and thyroid function of patients with RTH be followed very closely and that nociceptive stimulus of the surgery and postoperative pain be reduced as much as possible.
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Authors | Michiko Sugita, Hana Harada, Tatsuo Yamamoto |
Journal | Journal of anesthesia
(J Anesth)
Vol. 26
Issue 4
Pg. 595-7
(Aug 2012)
ISSN: 1438-8359 [Electronic] Japan |
PMID | 22388929
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Receptors, Thyroid Hormone
- Thyroid Hormones
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Topics |
- Adult
- Anesthesia, General
- Carcinoma, Papillary
(surgery)
- Female
- Hormone Replacement Therapy
- Humans
- Magnetic Resonance Imaging
- Mutation
(physiology)
- Pain, Postoperative
(therapy)
- Perioperative Care
- Postoperative Complications
(therapy)
- Receptors, Thyroid Hormone
(genetics)
- Thyroid Function Tests
- Thyroid Hormone Resistance Syndrome
(complications, genetics)
- Thyroid Hormones
(blood, therapeutic use)
- Thyroid Neoplasms
(surgery)
- Thyroidectomy
(methods)
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