L-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia.

Abstract

3-n-Butylphthalide (NBP) has been shown to have protective effects against ischemic stroke. In the present study, we investigated effects of l-3-n-butylphthalide (l-NBP) on the learning and memory impairment induced by chronic cerebral ischemia in rats. Male Wistar rats were administered 20 mg/kg l-NBP by gavage daily for 30 days after the bilateral common carotid artery clamping (two-vessel occlusion, 2-VO). Results showed that daily treatments of 20 mg/kg l-NBP significantly attenuated spatial learning deficits in Morris water maze (MWM) task. Results of long-term potentiation (LTP) indicated that treatment with 20 mg/kg l-NBP attenuated the inhibition of LTP in rat model of 2-VO. Moreover, l-NBP reduced glial fibrillary acidic protein (GFAP)-positive astrocytes induced by chronic cerebral ischemia. The present findings demonstrate the protective effect of l-NBP on chronic cerebral ischemia-induced hippocampus injury, which supports using l-NBP for therapy of cerebral ischemia in the future.

• Authors: Jing Xu, Yiyi Wang, Ning Li, Lanju Xu, Hanyu Yang, Zhuo Yang
• Journal: Neuropharmacology (Neuropharmacology) Vol. 62 Issue 7 Pg. 2424-9 (Jun 2012) ISSN: 1873-7064 [Electronic] England
• PMID: 22386716 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Benzofurans
• Neuroprotective Agents
• 3-n-butylphthalide

Topics

• Animals
• Benzofurans (pharmacology, therapeutic use)
• Brain Ischemia (drug therapy, pathology, psychology)
• Chronic Disease
• Cognition Disorders (drug therapy, pathology, psychology)
• Male
• Maze Learning (drug effects, physiology)
• Neuroprotective Agents (therapeutic use)
• Random Allocation
• Rats
• Rats, Wistar