L-3-n-butylphthalide improves cognitive deficits in rats with chronic cerebral ischemia.

3-n-Butylphthalide (NBP) has been shown to have protective effects against ischemic stroke. In the present study, we investigated effects of l-3-n-butylphthalide (l-NBP) on the learning and memory impairment induced by chronic cerebral ischemia in rats. Male Wistar rats were administered 20 mg/kg l-NBP by gavage daily for 30 days after the bilateral common carotid artery clamping (two-vessel occlusion, 2-VO). Results showed that daily treatments of 20 mg/kg l-NBP significantly attenuated spatial learning deficits in Morris water maze (MWM) task. Results of long-term potentiation (LTP) indicated that treatment with 20 mg/kg l-NBP attenuated the inhibition of LTP in rat model of 2-VO. Moreover, l-NBP reduced glial fibrillary acidic protein (GFAP)-positive astrocytes induced by chronic cerebral ischemia. The present findings demonstrate the protective effect of l-NBP on chronic cerebral ischemia-induced hippocampus injury, which supports using l-NBP for therapy of cerebral ischemia in the future.
AuthorsJing Xu, Yiyi Wang, Ning Li, Lanju Xu, Hanyu Yang, Zhuo Yang
JournalNeuropharmacology (Neuropharmacology) Vol. 62 Issue 7 Pg. 2424-9 (Jun 2012) ISSN: 1873-7064 [Electronic] England
PMID22386716 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2012 Elsevier Ltd. All rights reserved.
Chemical References
  • Benzofurans
  • Neuroprotective Agents
  • 3-n-butylphthalide
  • Animals
  • Benzofurans (pharmacology, therapeutic use)
  • Brain Ischemia (drug therapy, pathology, psychology)
  • Chronic Disease
  • Cognition Disorders (drug therapy, pathology, psychology)
  • Male
  • Maze Learning (drug effects, physiology)
  • Neuroprotective Agents (therapeutic use)
  • Random Allocation
  • Rats
  • Rats, Wistar

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