Usefulness of heart-type fatty acid-binding protein in patients with severe sepsis.

Abstract

PURPOSE:

The purpose of the study was to evaluate the value of heart-type fatty acid-binding protein (hFABP) as a novel clinical biomarker in patients with severe sepsis.

METHODS:

Serum concentrations of hFABP and traditional cardiac biomarkers including cardiac troponin I, creatine kinase-MB, and B-type natriuretic peptides levels were measured within 6 hours after admission in 93 severe septic patients. The value of hFABP for the diagnosis of sepsis-related myocardial dysfunction (SRMD) and for the prediction of 28-day mortality was evaluated by receiver operating characteristics curve analysis. The prognostic value of elevated hFABP was subsequently confirmed by multivariate Cox proportional hazards analysis and Kaplan-Meier survival analysis.

RESULTS:

Heart-type fatty acid-binding protein was elevated (≥ 4.5 ng/mL) in 58 (62.4%) patients; patients with elevated hFABP appeared more likely to have SRMD (84.5% vs 31.4%, P < .001) and have higher prevalence of 28-day death (37.9% vs 8.6%, P = .002). Heart-type fatty acid-binding protein offered superior value over conventional biomarkers in both diagnosis of SRMD (area under the curve, 0.767; P < .001) and prediction of 28-day death (area under the curve, 0.805; P < .001).

CONCLUSIONS:

Serum hFABP is frequently elevated among patients with severe sepsis and appears to be associated with SRMD. Elevated hFABP independently predicts 28-day mortality in severe sepsis.

• Authors: Zhao-cai Zhang, Hai-wen Dai, Yi-hua Yu, Ji-dong Yang, Cai-bao Hu
• Journal: Journal of critical care (J Crit Care) Vol. 27 Issue 4 Pg. 415.e13-8 (Aug 2012) ISSN: 1557-8615 [Electronic] United States
• PMID: 22386224 (Publication Type: Journal Article)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers
• FABP3 protein, human
• Fatty Acid Binding Protein 3
• Fatty Acid-Binding Proteins
• Troponin I
• Natriuretic Peptide, Brain
• Creatine Kinase, MB Form

Topics

• Adult
• Age Factors
• Aged
• Aged, 80 and over
• Biomarkers (blood)
• Creatine Kinase, MB Form (biosynthesis)
• Fatty Acid Binding Protein 3
• Fatty Acid-Binding Proteins (biosynthesis, blood)
• Female
• Health Status Indicators
• Humans
• Intensive Care Units (statistics & numerical data)
• Kaplan-Meier Estimate
• Male
• Middle Aged
• Natriuretic Peptide, Brain (biosynthesis)
• Prognosis
• Proportional Hazards Models
• Sensitivity and Specificity
• Sepsis (blood, diagnosis, mortality)
• Sex Factors
• Troponin I (biosynthesis)