Small non-coding RNAs govern mammary gland tumorigenesis.

Abstract

Small non-coding RNAs include siRNA, miRNA, piRNA and snoRNA. The involvement of miRNAs in the regulation of mammary gland tumorigenesis has been widely studied while the role for other small non-coding RNAs remains unclear. Here we summarize the involvement of miRNA in breast cancer onset and progression through regulating the cell cycle and cellular proliferation. The regulation of breast cancer stem cells and tumor regeneration by miRNA is reviewed. In addition, the emerging evidence demonstrating the involvement of piRNA and snoRNA in breast cancer is briefly described.

• Authors: Zuoren Yu, Richard G Pestell
• Journal: Journal of mammary gland biology and neoplasia (J Mammary Gland Biol Neoplasia) Vol. 17 Issue 1 Pg. 59-64 (Mar 2012) ISSN: 1573-7039 [Electronic] United States
• PMID: 22382486 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Review)

Chemical References

• RNA, Small Untranslated

Topics

• Animals
• Breast Neoplasms (genetics, pathology)
• Cell Transformation, Neoplastic (genetics, pathology)
• Female
• Humans
• Mammary Glands, Human (growth & development, pathology, physiology)
• RNA, Small Untranslated (genetics)