[Prevention of acute stress ulcer and gastrointestinal bleeding in patients with acute necrotizing pancreatitis].

Abstract

UNLABELLED:

We aimed to compare the efficiency of drugs for prevention a gastrointestinal bleeding.

OBJECTIVE:

The results of prospective and retrospective clinical study of 51 patients with acute necrotizing pancreatitis ANP. They were distributed assigned depending on the drug for the prevention of gastrointestinal bleeding in the first group (n = 39) used omeprazole (80 mg/day); in second (n = 12) pantoprazole (80 mg/day). The mean age (47,9 +/- 10,6 +/- 9,2) years, the severity of disease (average rating of APACHE II classification system 16,7 +/- 4,5 vs. 14,8 +/- 3,4) were similar. Our data discover that there no statistical difference between groups in bleeding rate.

CONCLUSION:

pantoprazole can be used for prevention of hemorrhagic complication of stress ulcer in patients with necrotizing pancreatitis. A high percentage of hidden blood loss confirms the need for drugs with high therapeutic potential

• Journal: Anesteziologiia i reanimatologiia (Anesteziol Reanimatol) 2011 Nov-Dec Issue 6 Pg. 74-8 ISSN: 0201-7563 [Print] Russia (Federation)
• PMID: 22379923 (Publication Type: Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• 2-Pyridinylmethylsulfinylbenzimidazoles
• Anti-Ulcer Agents
• Proton Pump Inhibitors
• Pantoprazole
• Omeprazole

Topics

• 2-Pyridinylmethylsulfinylbenzimidazoles (therapeutic use)
• Adult
• Anti-Ulcer Agents (therapeutic use)
• Female
• Gastrointestinal Hemorrhage (etiology, prevention & control)
• Humans
• Male
• Middle Aged
• Omeprazole (therapeutic use)
• Pancreatitis, Acute Necrotizing (complications, physiopathology)
• Pantoprazole
• Peptic Ulcer (etiology, prevention & control)
• Prospective Studies
• Proton Pump Inhibitors (therapeutic use)
• Retrospective Studies
• Severity of Illness Index