66 patients underwent cognate
liver transplantation were divided into three groups. First received fresh frozen plasma and crystalloids at the ratio of 1:2 Second group FFP and crystalloids at the ratio of 1:1. Third at the ratio of 2:1 FFP and crystalloids. pH, SBC, PCO2,
lactate was measured at the period of cross-clamping vena cava (anhepatic phase) and at the end of the surgery. As well as
anion difference (AD), excess and deficiency of
anion difference HCO3 = [(AD-12/24-HCO3)] or difference difference.
RESULTS: First group of patient who received FFP 5423+ 417 ml. and crystalloids 11048+ 458 ml. demonstrated
metabolic acidosis pH 7,309+0,02 and 7,323+0,01; SBC 17,72+0,96 and 18,36+1,76 mmoll/l;
lactate 3,0+1,08 and 2,33+1,16 mmoll/l; difference difference 0,47+0,13 and 0,51 +0,25;
chlorine 114,65+1,5 and 114,25+0,7 mmoll/l. At the end of anhepatic phase and at end of the operation the
acidosis formed because of increased level of
lactate as well as hyperchloremia due to infusion of high dose of fluids with high concentration of
chlorine intravenous. Second group received 6882+ 943 ml. of FFP and 6690+882 ml. of crystalloids. There was a tendency to
metabolic acidosis at the end of anhepatic phase pH 7,354+0,061; SBC 22,73+0,94;
lactate 3,3+0,98 mmoll/l ;AD 12,85+0,86 mmol/l and difference difference 1,00+0,048,
chlorine 100,76+1,39mmol/l. The main factor of
metabolic acidosis was increased level of
lactate. The third group with received 7532+1196ml. of FFP and 3720+629 ml. crystalloids.
Metabolic acidosis developed at the end of anhepatic period pH 7,346+0,038; SBC21,28+0,95mmol/l;
lactate 2,72+0,97mmol/l; AD 14,72+0,97mmol/l and difference difference 1,00+0,06;
chlorine 100,95+2,49mmol/l. The main reason of
acidosis was
lactate, at the end of the operation there was an metabolic
alkalosis pH 7,460+0,039; SBC 29,28+2,63mmol/l;
lactate 2,81+1,66mmol/l.
CONCLUSION: