Abstract |
The immunohistochemical study of proliferation and intermediate filament-- keratin 8 expressions at oral hyperkeratosis and oral Squamous cell carcinoma (OSCC) has been carried out. It has been shown, that the specific character of keratin 8 expressions can be used in differential diagnosis between oral hyperkeratosis and OSCC. Different types of oral hyperkeratosis (without atypia, SIN1, SIN2 and SIN3) can be differentiated by Ki-67 and keratin 8. We have found the moderate positive correlation between proliferation and a keratin 8 expression in neoplastic epithelial cells.
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Authors | I I Babichenko, A S Grigor'ian, A A Katushkina |
Journal | Arkhiv patologii
(Arkh Patol)
2011 Nov-Dec
Vol. 73
Issue 6
Pg. 18-21
ISSN: 0004-1955 [Print] Russia (Federation) |
PMID | 22379894
(Publication Type: English Abstract, Journal Article)
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Chemical References |
- Biomarkers, Tumor
- KRT8 protein, human
- Keratin-8
- Ki-67 Antigen
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Topics |
- Biomarkers, Tumor
(biosynthesis, genetics)
- Carcinoma, Squamous Cell
(diagnosis, metabolism, pathology)
- Cell Proliferation
- Diagnosis, Differential
- Epithelial Cells
(metabolism, pathology)
- Female
- Humans
- Immunohistochemistry
- Keratin-8
(biosynthesis, genetics)
- Ki-67 Antigen
(biosynthesis)
- Leukoplakia, Oral
(diagnosis, metabolism, pathology)
- Male
- Middle Aged
- Mouth Mucosa
(metabolism, pathology)
- Mouth Neoplasms
(diagnosis, metabolism, pathology)
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