[Efficacy of emoxipine and mexidol in patients with chronic disorders of the digestive system and atherosclerosis of the abdominal aorta].

Abstract

The influence of emoxipine (2-ethyl-6-methyl-3-hydroxypyridine hydrochloride) and mexidol (2-ethyl-6-methyl-3-hydroxypyridine succinate) on the content of lipid peroxidation products in peripheral blood and the dynamics of clinical symptoms of gastrointestinal tract pathology has been studied in patients of middle and senile age with atherosclerosis in the abdominal aorta. It is established that a two-week 3-hydroxypyridine derivatives leads to a decrease in the level of lipid peroxidation products. The administration of emoxipine led to the most pronounced control of pain.

• Authors: A I Dolgushina
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 74 Issue 12 Pg. 11-4 ( 2011) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 22379875 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Antioxidants
• Lipid Peroxides
• Picolines
• emoxypine succinate
• 6-methyl-2-ethyl-3-hydroxypyridine

Topics

• Abdominal Pain (complications, prevention & control)
• Aged
• Antioxidants (administration & dosage, therapeutic use)
• Aorta, Abdominal (pathology)
• Atherosclerosis (complications, drug therapy, metabolism, pathology)
• Chronic Disease
• Digestive System Diseases (complications, drug therapy, metabolism, pathology)
• Female
• Humans
• Infusions, Intravenous
• Lipid Peroxidation (drug effects)
• Lipid Peroxides (blood)
• Male
• Picolines (administration & dosage, therapeutic use)
• Single-Blind Method
• Treatment Outcome