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[Effect of compatibilities and proportions of shuanglong formula on acute myocardial infarction in rats].

AbstractOBJECTIVE:
To verify the rational of Chinese medicine Shuanglong formula.
METHOD:
Rat models of acute myocardial ischemia were induced by hydrochloride isoproterenol. ECG J point change, myocardial infarction area and cellular enzyme (CK, LDH, SOD and MDA) levels were observed and detected to show protective effect of treatment groups.
RESULT:
The single drug prescriptions and compatibilities both could improve ECG performance, decrease levels of CK, LDH, SOD and MDA in serum, and reduce a certain myocardial infarct size.
CONCLUSION:
The Shuanglong formula at the high dose of 3:7 was proved to be more effective on myocardial ischemia.
AuthorsXiaoping Liang, Xi Chen, Yiming Wang, Qionglin Liang, Jun Wu, Guoan Luo
JournalZhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica (Zhongguo Zhong Yao Za Zhi) Vol. 36 Issue 22 Pg. 3176-9 (Nov 2011) ISSN: 1001-5302 [Print] China
PMID22375402 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Drugs, Chinese Herbal
  • shuanglong
  • Isoproterenol
Topics
  • Animals
  • Disease Models, Animal
  • Drugs, Chinese Herbal (administration & dosage)
  • Electrocardiography (drug effects)
  • Isoproterenol
  • Male
  • Myocardial Infarction (drug therapy)
  • Rats
  • Rats, Sprague-Dawley

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