[Atrial fibrillation in an acute stroke unit].

Contrasting with the abundant literature dedicated to atrial fibrillation (AF) and to the use of new oral anticoagulants in this setting, very few recent studies have focused on patients with AF-associated stroke. From November 2010 to March 2011, we conducted a small prospective 4-month study in the stroke units of Lariboisière and Bicêtre hospitals. Fifty patients with FA and stroke were included (14% of all strokes), including 45 patients with cerebral infarcts (CI), 3 with transient ischemic attacks (TIA) and 2 with intracerebral hemorrhage (ICH). The results of this study, together with a review of the sparse relevant literature, underline the following points: these patients tend to be older and more frequently female than in recent clinical trials; TIAs are rare; these patients have numerous vascular risk factors and associated cerebrovascular diseases such as atheroma and leukoaraiosis; CI is often extensive and hemorrhagic; AF is discovered in a stroke unit in 40% of cases and is paroxystic in 33% of cases, with no consensus on the potential regulation; there is massive underuse of VKA in patients with known AF; rtPA intravenous thrombolysis is frequent; treatment difficulties arise in patients with AF-related CI and a history of ICH; the prognosis of VKA-related ICH is poor; the use of oral anticoagulants alone or combined with aspirin is controversial in case of AF associated with severe atheroma. Patients with AF seen in stroke units are therefore very different from those seen by cardiologists: they are older and have many vascular risk factors, stroke, and other cerebrovascular lesions, raising difficult treatment issues owing to the dual risk of embolic recurrence and symptomatic hemorrhagic transformation. In addition, contraindications to long-term VKA use are frequent. Many of these issues will again be raised with the arrival of new oral anticoagulants.
AuthorsElsa Melki, Jérôme Mawet, Mariana Sarov-Riviere, Marie-Germaine Bousser
JournalBulletin de l'Académie nationale de médecine (Bull Acad Natl Med) 2011 Apr-May Vol. 195 Issue 4-5 Pg. 987-1000; discussion 1000-1 ISSN: 0001-4079 [Print] Netherlands
Vernacular TitleLa fibrillation atriale en unité de soins intensifs neuro- vasculaire (USINV).
PMID22375365 (Publication Type: English Abstract, Journal Article)
Chemical References
  • Anticoagulants
  • Fibrinolytic Agents
  • Tissue Plasminogen Activator
  • Aged
  • Aged, 80 and over
  • Anticoagulants (contraindications, therapeutic use)
  • Atrial Fibrillation (complications)
  • Female
  • Fibrinolytic Agents (therapeutic use)
  • Hospital Units
  • Humans
  • Intracranial Hemorrhages (etiology)
  • Male
  • Middle Aged
  • Prospective Studies
  • Risk Factors
  • Stroke (etiology, therapy)
  • Thrombectomy
  • Tissue Plasminogen Activator (therapeutic use)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!

Choose Username:
Verify Password: