Rhodopsin is a
visual pigment present in rod cells of retina. It belongs to GPCR family and involves photoisomerization of
11-cis-retinal to
all-trans-retinal isomers, conformational changes in
rhodopsin and signal transduction cascade to generate a nerve impulse. This signaling pathway has been targeted to eliminate the effect of a mutation (Gly90→Asp) responsible for abnormal activation of
G-protein without
retinal conformations in the absence of light leading to congenital
night blindness. A theoretical model of
rhodopsin with induced mutation has been deliberated in order to find potential
ligands which can offset this mutational effect. The binding interactions between the target mutated
rhodopsin model and potential
ligands have been predicted with the help of molecular docking. The results indicated strong functional benefits of
ligands as an inhibitor and an agonist for mutated
rhodopsin model. Therefore, we propose a new visual cascade model which can initiate the normal signaling of
rhodopsin mutant with the help of proposed
ligands and can provide a hope for vision in future.