Abstract |
A long-term administration of Indobufen, 400 mg daily, was evaluated in 57 patients with cardiovascular diseases. Aggregation waves induced by ADP, collagen and epinephrine showed a significant and persistent inhibition of platelet function. Minor side effects were observed and in 6 patients the drug was withdrawn: 4 patients began to experience gastric troubles, 1 patient had positive occult test for blood, 1 patient developed an allergic rush. Clinical evaluation and platelet aggregation study before starting indobufen and during the follow up period seem to be useful in the evaluation of effectiveness, safety, compliance and suitable daily dose.
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Authors | A Andriani, G Mosiello, M G Chiappetta, G Gregori, P Rinaldi |
Journal | Recenti progressi in medicina
(Recenti Prog Med)
Vol. 81
Issue 1
Pg. 49-53
(Jan 1990)
ISSN: 0034-1193 [Print] Italy |
Vernacular Title | Valutazione clinico-ematologica di 57 pazienti in trattamento antiaggregante con indobufene. |
PMID | 2236828
(Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article)
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Chemical References |
- Isoindoles
- Phenylbutyrates
- Platelet Aggregation Inhibitors
- indobufen
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Topics |
- Cardiovascular Diseases
(blood, drug therapy)
- Female
- Humans
- Isoindoles
- Male
- Middle Aged
- Phenylbutyrates
(administration & dosage, adverse effects, therapeutic use)
- Platelet Aggregation Inhibitors
(administration & dosage, adverse effects, therapeutic use)
- Time Factors
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