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Initial experience from a double-blind, placebo-controlled, clinical outcome study of ARC1779 in patients with thrombotic thrombocytopenic purpura.

AuthorsSpero R Cataland, Flora Peyvandi, Pier M Mannucci, Bernhard Lämmle, Johanna A Kremer Hovinga, Samuel J Machin, Marie Scully, Gail Rock, James C Gilbert, Shangbin Yang, Haifeng Wu, Bernd Jilma, Paul Knoebl
JournalAmerican journal of hematology (Am J Hematol) Vol. 87 Issue 4 Pg. 430-2 (Apr 2012) ISSN: 1096-8652 [Electronic] United States
PMID22367751 (Publication Type: Letter, Multicenter Study, Randomized Controlled Trial)
Chemical References
  • ARC 1779
  • Aptamers, Nucleotide
  • Immunosuppressive Agents
  • von Willebrand Factor
  • ADAM Proteins
  • ADAMTS13 Protein
  • ADAMTS13 protein, human
Topics
  • ADAM Proteins (blood)
  • ADAMTS13 Protein
  • Adult
  • Aptamers, Nucleotide (administration & dosage, adverse effects, therapeutic use)
  • Catheter-Related Infections (etiology)
  • Combined Modality Therapy
  • Consciousness Disorders (etiology)
  • Double-Blind Method
  • Early Termination of Clinical Trials
  • Epilepsy (etiology)
  • Female
  • Humans
  • Immunosuppressive Agents (therapeutic use)
  • Infusions, Intravenous (adverse effects)
  • Male
  • Middle Aged
  • Plasma Exchange
  • Platelet Count
  • Protein Binding (drug effects)
  • Protein Structure, Tertiary
  • Purpura, Thrombotic Thrombocytopenic (complications, drug therapy, physiopathology, therapy)
  • von Willebrand Factor (antagonists & inhibitors, physiology)

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