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Treatment of localized psoriasis with a topical formulation of zinc pyrithione.

AbstractBACKGROUND:
Psoriasis is a common chronic condition of the skin that is resistant to many therapies.
AIM:
To test the efficacy of a topical formulation of zinc pyrithione in an emollient base compared with an emollient alone in the treatment of psoriasis.
METHODS:
This was a randomized double-blind clinical trial. Patients with localized psoriasis involving less than 10% of body skin areas were enrolled in the study. They were randomly allocated to one of two treatment groups. Group A was treated with emollient cream containing 0.25% zinc pyrithione and group B was treated with emollient cream alone twice daily for 3 months. Response to treatment was assessed using PASI scores.
RESULTS:
Of 60 participants, 30 patients in group A and 30 patients in group B completed the study. The mean PASI scores before and after treatment were 3.4±1.8 and 0.9±1.3 in group A (p<0.01), and 4.3±2 and 3.9±1.3 in group B (p>0.05), and there was a significant difference between the two groups' mean PASI scores at the end of the study (p<0.01). The differences in the mean PASI scores before and after treatment were 2.4±2 and 0.4±0.1 in groups A and B, respectively (p<0.01).
CONCLUSION:
A topical formulation of zinc pyrithione can be used to treat localized psoriasis.
AuthorsG Sadeghian, H Ziaei, M A Nilforoushzadeh
JournalActa dermatovenerologica Alpina, Pannonica, et Adriatica (Acta Dermatovenerol Alp Pannonica Adriat) Vol. 20 Issue 4 Pg. 187-90 ( 2011) ISSN: 1581-2979 [Electronic] Slovenia
PMID22367374 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Emollients
  • Keratolytic Agents
  • Organometallic Compounds
  • Pyridines
  • pyrithione zinc
Topics
  • Administration, Topical
  • Adult
  • Double-Blind Method
  • Emollients
  • Female
  • Humans
  • Keratolytic Agents (therapeutic use)
  • Male
  • Organometallic Compounds (therapeutic use)
  • Psoriasis (drug therapy)
  • Pyridines (therapeutic use)

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