Abstract | BACKGROUND: AIM: METHODS: This was a randomized double-blind clinical trial. Patients with localized psoriasis involving less than 10% of body skin areas were enrolled in the study. They were randomly allocated to one of two treatment groups. Group A was treated with emollient cream containing 0.25% zinc pyrithione and group B was treated with emollient cream alone twice daily for 3 months. Response to treatment was assessed using PASI scores. RESULTS: Of 60 participants, 30 patients in group A and 30 patients in group B completed the study. The mean PASI scores before and after treatment were 3.4±1.8 and 0.9±1.3 in group A (p<0.01), and 4.3±2 and 3.9±1.3 in group B (p>0.05), and there was a significant difference between the two groups' mean PASI scores at the end of the study (p<0.01). The differences in the mean PASI scores before and after treatment were 2.4±2 and 0.4±0.1 in groups A and B, respectively (p<0.01). CONCLUSION:
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Authors | G Sadeghian, H Ziaei, M A Nilforoushzadeh |
Journal | Acta dermatovenerologica Alpina, Pannonica, et Adriatica
(Acta Dermatovenerol Alp Pannonica Adriat)
Vol. 20
Issue 4
Pg. 187-90
( 2011)
ISSN: 1581-2979 [Electronic] Slovenia |
PMID | 22367374
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Emollients
- Keratolytic Agents
- Organometallic Compounds
- Pyridines
- pyrithione zinc
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Topics |
- Administration, Topical
- Adult
- Double-Blind Method
- Emollients
- Female
- Humans
- Keratolytic Agents
(therapeutic use)
- Male
- Organometallic Compounds
(therapeutic use)
- Psoriasis
(drug therapy)
- Pyridines
(therapeutic use)
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