Abstract | BACKGROUND AND OBJECTIVES: DESIGN AND SETTING: A retrospective, case-control study at Antai Tian-Sheng Memorial Hospital from 1 January to 31 December 2009. SUBJECTS AND METHODS: Of 300 subjects enrolled in the study, 132 were obese (BMI≥30 kg/m2) and 168 controls were not obese (BMI≤24 kg/m2). The polymorphisms of GAD2 (+61450 C/A), (+83987 T/A) and DRD2 (S311C) were characterized, respectively, by polymerase chain reaction-restriction fragment length polymorphism. The genotype and allele frequencies of the polymorphisms in this study were statistically analyzed. RESULTS: The genotype and allele frequencies of the GAD2 (+83987 T/A) and DRD2 (S311C) were significantly different between cases and controls (P=.001 for both). The frequencies of TT genotype and T allele of the GAD2 (+83987 T/A) as well as the frequencies of Ser/Cys genotype and Cys allele of DRD2 (S311C) were higher in cases compared to controls (P=.034 and =.036 for both). CONCLUSIONS: The study demonstrated a statistically significant difference in the frequency of the GAD2 (+83987 T/A) and DRD2 (S311C) genes between cases and controls in Taiwanese subjects.
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Authors | Ke-Chang Chen, Yi-Chen Lin, Wen-Chii Chao, Hsieh-Kun Chung, Su-Sheng Chi, Wen-Sheng Liu, Wen-Tung Wu |
Journal | Annals of Saudi medicine
(Ann Saudi Med)
2012 Mar-Apr
Vol. 32
Issue 2
Pg. 121-6
ISSN: 0975-4466 [Electronic] Saudi Arabia |
PMID | 22366823
(Publication Type: Journal Article)
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Chemical References |
- Receptors, Dopamine D2
- Glutamate Decarboxylase
- glutamate decarboxylase 2
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Topics |
- Adult
- Alleles
- Body Mass Index
- Case-Control Studies
- Female
- Gene Frequency
- Genetic Association Studies
- Genetic Predisposition to Disease
- Genotype
- Glutamate Decarboxylase
(genetics)
- Humans
- Male
- Middle Aged
- Obesity
(genetics)
- Polymerase Chain Reaction
- Polymorphism, Restriction Fragment Length
- Receptors, Dopamine D2
(genetics)
- Retrospective Studies
- Taiwan
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