Bilateral diffuse orbital myositis in a patient with relapsing ulcerative colitis.

Abstract

Ophthalmic manifestations of inflammatory bowel disease are common, but orbital inflammatory disease is rare with most cases associated with Crohn disease. We describe the first case of bilateral, diffuse, orbital myositis associated with ulcerative colitis in a patient taking infliximab. Within 72 hours of intravenous methylprednisolone treatment, the orbital inflammation dramatically improved. After 8 weeks of prednisone, it completely resolved and has remained quiet for 13 months. This is only the third report of ulcerative colitis-associated orbital inflammatory disease.

• Authors: John Bennion, Matheson A Harris, Jennifer A Sivak-Callcott, John Nguyen
• Journal: Ophthalmic plastic and reconstructive surgery (Ophthalmic Plast Reconstr Surg) 2012 Sep-Oct Vol. 28 Issue 5 Pg. e119-20 ISSN: 1537-2677 [Electronic] United States
• PMID: 22366668 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Glucocorticoids
• Infliximab
• Methylprednisolone

Topics

• Antibodies, Monoclonal (therapeutic use)
• Colitis, Ulcerative (complications, drug therapy)
• Glucocorticoids (therapeutic use)
• Humans
• Infliximab
• Male
• Methylprednisolone (therapeutic use)
• Middle Aged
• Oculomotor Muscles (diagnostic imaging, pathology)
• Orbital Myositis (diagnostic imaging, drug therapy, etiology)
• Recurrence
• Tomography, X-Ray Computed