Abstract | OBJECTIVES:
Pioglitazone delayed the development of seizure responses and shortened the duration of convulsion of genetically epileptic EL mice. The anti-epileptic effect of pioglitazone was attributed partly through the reduction of inflammatory responses and preventing apoptosis. There are also some reports showing that some pioglitazone effects mediate through nitric oxide. In this study we evaluated sub-chronic pioglitazone effects in two models of intravenous and intraperitoneal pentylenetetrazole-induced clonic seizures in mice. MATERIALS AND METHODS: RESULTS: CONCLUSION:
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Authors | Hamed Shafaroodi, Leila Moezi, Hassan Ghorbani, Meysam Zaeri, Sara Hassanpour, Mahsa Hassanipour, Ahmad Reza Dehpour |
Journal | Brain research bulletin
(Brain Res Bull)
Vol. 87
Issue 6
Pg. 544-50
(Apr 10 2012)
ISSN: 1873-2747 [Electronic] United States |
PMID | 22366335
(Publication Type: Journal Article)
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Copyright | Copyright © 2012 Elsevier Inc. All rights reserved. |
Chemical References |
- Anticonvulsants
- Enzyme Inhibitors
- Thiazolidinediones
- Nitric Oxide
- NG-Nitroarginine Methyl Ester
- Pentylenetetrazole
- Pioglitazone
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Topics |
- Analysis of Variance
- Animals
- Anticonvulsants
(chemistry, therapeutic use)
- Disease Models, Animal
- Drug Administration Routes
- Drug Interactions
- Enzyme Inhibitors
(pharmacology)
- Male
- Mice
- NG-Nitroarginine Methyl Ester
(pharmacology)
- Nitric Oxide
(physiology)
- Pentylenetetrazole
(toxicity)
- Pioglitazone
- Seizures
(chemically induced, drug therapy)
- Thiazolidinediones
(chemistry, therapeutic use)
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