Abstract | OBJECTIVES: ANIMALS, MATERIALS AND METHODS: Seven client-owned dogs with stable CHF receiving twice daily oral furosemide and adjunctive medications. Utilizing a double-blinded, randomized, crossover design, dogs were administered either oral furosemide at their current dose or an equivalent oral dose of torsemide (1/10 of the daily furosemide dose divided into twice daily dosing) on day 0. Crossover occurred at day 7 and the study ended on day 14. Clinical, laboratory, radiographic, and QOL variables were evaluated on days 0, 7 and 14. RESULTS: No dogs developed recurrent CHF during the study. Mean furosemide dose on day 0 was 5.13 mg/kg/day (range 2.8-9.6). Following torsemide treatment, creatinine (P = 0.020), urea nitrogen (P = 0.013), phosphorus (P = 0.032), albumin (P = 0.019), carbon dioxide (P = 0.015) and anion gap (P = 0.005) were significantly increased, and urine specific gravity (P = 0.004) and chloride (P = 0.021) were significantly decreased compared with furosemide dosing. No differences in QOL were found. CONCLUSIONS:
|
Authors | Gordon D Peddle, Gretchen E Singletary, Caryn A Reynolds, Dennis J Trafny, Maggie C Machen, Mark A Oyama |
Journal | Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology
(J Vet Cardiol)
Vol. 14
Issue 1
Pg. 253-9
(Mar 2012)
ISSN: 1875-0834 [Electronic] Netherlands |
PMID | 22364690
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Copyright | Copyright © 2012. Published by Elsevier B.V. |
Chemical References |
- Diuretics
- Sulfonamides
- Furosemide
- Torsemide
|
Topics |
- Animals
- Cross-Over Studies
- Diuretics
(therapeutic use)
- Dog Diseases
(drug therapy)
- Dogs
- Furosemide
(therapeutic use)
- Heart Failure
(drug therapy, etiology, veterinary)
- Mitral Valve Insufficiency
(complications, veterinary)
- Sulfonamides
(therapeutic use)
- Torsemide
|