Cytotoxic and antitumor constituents in pericarps of Mallotus japonicus.

Abstract

A variety of phloroglucinol derivatives isolated from the pericarps of Mallotus japonicus were assessed for growth inhibiting activity against human larynx (HEp-2) and lung (PC-13) carcinoma cells as well as mouse B16 melanoma, leukemia P388, and L5178Y cells. Most of these derivatives were proved to be significantly cytotoxic in culture. One of them, 3-(3,3-dimethylallyl)-5-(3-acetyl-2,4-dihydroxy-5-methyl-6-methoxybenzyl )- phloracetophenone showed an excellent cytotoxicity against all target tumor cells and a marked prolongation of life-span in mice bearing L5178Y leukemia.

• Authors: M Arisawa, A Fujita, N Morita, S Koshimura
• Journal: Planta medica (Planta Med) Vol. 56 Issue 4 Pg. 377-9 (Aug 1990) ISSN: 0032-0943 [Print] Germany
• PMID: 2236292 (Publication Type: Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Immunologic Factors
• Picibanil

Topics

• Animals
• Antineoplastic Agents, Phytogenic (isolation & purification)
• Drug Therapy, Combination
• Humans
• Immunologic Factors (administration & dosage, pharmacology)
• Male
• Mice
• Neoplasms, Experimental (drug therapy)
• Picibanil (administration & dosage, pharmacology)
• Plants (analysis)
• Structure-Activity Relationship
• Tumor Cells, Cultured