Abstract | BACKGROUND: METHODS: This is a multicenter (francophone) observational study. Inclusion was based upon abnormal preoperative hormone tests in patients with pheochromocytoma that normalized after removal of the tumor. Where possible, immunohistochemistry was performed to confirm that ectopic secretion came from the tumor. RESULTS: Sixteen cases were found: nine female and seven male patients. Median age was 50.5 (range 31-89) years. Most presented with hypertension, diabetes, or cushingoid features. Ten patients had specific symptoms from the ectopic hormone secretion. Two had a familial syndrome. Of eight patients with excess cortisol secretion, three died as a result of the tumor resection: two had pheochromocytomas >15 cm and their associated cortisol hypersecretion complicated their postoperative course. The other died from a torn subhepatic vein. The 13 survivors did not develop any evidence of malignancy during follow-up (median 50 months). Symptoms from the ectopic secretion resolved after removal of the tumor. Immunohistochemistry was performed and was positive in eight tumors: five ACTH, three calcitonins, and one VIP. CONCLUSIONS:
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Authors | James Kirkby-Bott, Laurent Brunaud, Muriel Mathonet, Etienne Hamoir, Jean-Louis Kraimps, Christophe Trésallet, Laurence Amar, Alexandre Rault, Jean-Francois Henry, Bruno Carnaille |
Journal | World journal of surgery
(World J Surg)
Vol. 36
Issue 6
Pg. 1382-8
(Jun 2012)
ISSN: 1432-2323 [Electronic] United States |
PMID | 22362045
(Publication Type: Evaluation Study, Journal Article, Multicenter Study)
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Topics |
- ACTH Syndrome, Ectopic
(etiology, mortality, surgery)
- Adrenal Gland Neoplasms
(etiology, metabolism, mortality, surgery)
- Adrenalectomy
- Adult
- Aged
- Aged, 80 and over
- Belgium
- Female
- France
- Humans
- Male
- Middle Aged
- Pheochromocytoma
(etiology, metabolism, mortality, surgery)
- Retrospective Studies
- Risk Factors
- Treatment Outcome
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