Abstract | BACKGROUND: METHOD: The aerosol formulation of CAM (0.2 mg/kg) was administered to rat lungs using a Liquid MicroSprayer(®). The oral formulation of CAM (50 mg/kg) was used for comparison. Time courses of concentrations of CAM in ELF and AMs following administration were obtained, and then the bioavailability (BA) was calculated. In addition, the area under the concentrations of CAM in ELF and AMs-time curve/minimum inhibitory concentration at which 90% of isolates ratio [area under the curve (AUC/MIC(90))] were calculated to estimate the antibacterial effects in ELF and AMs. RESULTS: The BA of CAM in ELF and AMs following administration of aerosol formulation were markedly greater than that following administration of oral formulation. This indicates that the aerosol formulation is more effective in delivering CAM to ELF and AMs, compared with the oral formulation, despite a low dose. The AUC/MIC(90) of CAM in ELF and AMs were markedly higher than the effective values. This indicates that the aerosol formulation could be useful for the treatment of respiratory infections caused by pathogenic microorganisms infected in ELF and AMs. CONCLUSIONS:
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Authors | Kohei Togami, Sumio Chono, Kazuhiro Morimoto |
Journal | Journal of aerosol medicine and pulmonary drug delivery
(J Aerosol Med Pulm Drug Deliv)
Vol. 25
Issue 2
Pg. 110-5
(Apr 2012)
ISSN: 1941-2703 [Electronic] United States |
PMID | 22360316
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Aerosols
- Anti-Bacterial Agents
- Clarithromycin
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Topics |
- Administration, Inhalation
- Administration, Oral
- Aerosols
- Animals
- Anti-Bacterial Agents
(administration & dosage, pharmacokinetics)
- Area Under Curve
- Biological Availability
- Bronchoalveolar Lavage Fluid
- Clarithromycin
(administration & dosage, pharmacokinetics)
- Drug Delivery Systems
- Lung
(metabolism)
- Macrophages, Alveolar
(metabolism)
- Male
- Microbial Sensitivity Tests
- Rats
- Rats, Sprague-Dawley
- Respiratory Tract Infections
(drug therapy)
- Time Factors
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