Abstract | OBJECTIVES: METHODS: During 2007-08, 74 centres submitted 857 isolates of S. pneumoniae from patients with community-acquired bacterial pneumonia. These were re-identified and serotyped. MICs of ceftaroline and 12 comparators were determined by CLSI broth microdilution at a central laboratory. RESULTS:
Ceftaroline was very active against all 857 S. pneumoniae isolates (MIC(90) 0.12 mg/L). The MIC(50) for South African isolates was 0.06 mg/L compared with 0.004 or 0.008 mg/L for isolates from elsewhere. Antibiotic resistance was also higher in South Africa than other countries. Serotypes 3, 1, 7 and 11 were more susceptible to ceftaroline (MIC(90) = 0.008 mg/L) and the reference antibiotics than the population as a whole. Ceftaroline showed a biphasic MIC distribution (associated with cefuroxime susceptibility), the extent of which differed between isolate populations. Nevertheless, the highest ceftaroline MIC observed was only 0.5 mg/L (two isolates: one from the UK and one from South Africa). CONCLUSIONS: These data from a large collection of S. pneumoniae isolates during 2007-08 from Europe and South Africa with varying serotype and antibiotic susceptibility, confirm the excellent in vitro activity of ceftaroline against S. pneumoniae causing community-acquired bacterial pneumonia in both adults and children.
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Authors | Ian Morrissey, Anne Leakey |
Journal | The Journal of antimicrobial chemotherapy
(J Antimicrob Chemother)
Vol. 67
Issue 6
Pg. 1408-12
(Jun 2012)
ISSN: 1460-2091 [Electronic] England |
PMID | 22357801
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Anti-Bacterial Agents
- Cephalosporins
- T 91825
|
Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Anti-Bacterial Agents
(pharmacology)
- Cephalosporins
(pharmacology)
- Child
- Child, Preschool
- Community-Acquired Infections
(microbiology)
- Europe
- Female
- Humans
- Male
- Microbial Sensitivity Tests
- Middle Aged
- Pneumonia, Pneumococcal
(microbiology)
- Serotyping
- South Africa
- Streptococcus pneumoniae
(classification, isolation & purification)
- Young Adult
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