Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS: OC Cmax (1029 ± 478 ng/mL) and area under the curve (9.00 ± 4.52 mcg·h/mL) for patients on ECMO with preserved renal function were comparable with those of healthy volunteers or noncritically ill patients. Patients both on ECMO and CVVHDF had 4-to 5-fold higher OC Cmax and area under the curve. CONCLUSIONS: ECMO by itself did not impact on the pharmacokinetics of OC. However, the drug accumulated in the plasma of patients on ECMO who also received CVVHDF for renal failure. Based on these results, we recommend that oseltamivir dosage should be decreased and plasma levels of OC be monitored in patients receiving CVVHDF because of acute kidney injury.
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Authors | Florian Lemaitre, Charles-Edouard Luyt, François Roullet-Renoleau, Ania Nieszkowska, Noël Zahr, Emmanuel Corvol, Christine Fernandez, Marie Antignac, Robert Farinotti, Alain Combes |
Journal | Therapeutic drug monitoring
(Ther Drug Monit)
Vol. 34
Issue 2
Pg. 171-5
(Apr 2012)
ISSN: 1536-3694 [Electronic] United States |
PMID | 22354159
(Publication Type: Journal Article)
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Chemical References |
- Antiviral Agents
- Oseltamivir
- oseltamivir carboxylate
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Topics |
- Acute Kidney Injury
(etiology, therapy)
- Adult
- Antiviral Agents
(pharmacokinetics, therapeutic use)
- Area Under Curve
- Critical Illness
- Dose-Response Relationship, Drug
- Extracorporeal Membrane Oxygenation
(methods)
- Female
- Hemodiafiltration
(methods)
- Humans
- Influenza A Virus, H1N1 Subtype
(isolation & purification)
- Influenza, Human
(complications)
- Male
- Oseltamivir
(analogs & derivatives, pharmacokinetics, therapeutic use)
- Pandemics
- Respiratory Distress Syndrome
(etiology, therapy)
- Young Adult
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