Abstract |
The clinical usefulness and the optimal dose of Z-100 for the treatment of leukopenia caused by radiotherapy for malignant tumors was evaluated in a double-blind study comparing 20 micrograms and 30 micrograms injections of Z-100 and inosine (Z-20, Z-30 and IN group, respectively). The effective rate according to the evaluation by the attending physicians was 67.4%, 79.1% and 48.9% in the Z-30, Z-20 and IN groups, respectively, with a significantly higher efficacy rate for the Z-20 group than for the IN group. The frequency of adverse reactions was 14.3%, 3.9% and 5.6% in the Z-30, Z-20 and IN groups, respectively, with the highest rate in the Z-30 group, but there was no significant difference among the three groups. The useful rate based on total evaluation considering the effective rate and the safety profile in each group was 60.8%, 77.3% and 46.8% in the Z-30, Z-20 and IN groups, respectively, with the highest rate in the Z-20 group showing significant difference from that in the IN group. The above data confirmed the clinical usefulness of Z-100 and suggested that the optimal dose was 20 micrograms twice weekly for Z-100.
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Authors | S Hashimoto, T Ohkawa, Y Takekawa, J Horiuchi, T Mori, S Amino, K Morita, Y Tanaka, Y Mochizuki, T Yanagisawa |
Journal | Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica
(Nihon Igaku Hoshasen Gakkai Zasshi)
Vol. 50
Issue 8
Pg. 977-92
(Aug 25 1990)
ISSN: 0048-0428 [Print] Japan |
PMID | 2235345
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article, Multicenter Study)
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Chemical References |
- Adjuvants, Immunologic
- Lipids
- Mannans
- specific substance maruyama
- Inosine
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Topics |
- Adjuvants, Immunologic
(therapeutic use)
- Aged
- Double-Blind Method
- Female
- Humans
- Inosine
(therapeutic use)
- Japan
- Leukopenia
(drug therapy, etiology)
- Lipids
(therapeutic use)
- Male
- Mannans
(therapeutic use)
- Middle Aged
- Neoplasms
(radiotherapy)
- Radiotherapy
(adverse effects)
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