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[Clinical efficacy of Z-100 for the treatment of leukopenia caused by radiotherapy--a multi-center double-blind comparative study with inosine].

Abstract
The clinical usefulness and the optimal dose of Z-100 for the treatment of leukopenia caused by radiotherapy for malignant tumors was evaluated in a double-blind study comparing 20 micrograms and 30 micrograms injections of Z-100 and inosine (Z-20, Z-30 and IN group, respectively). The effective rate according to the evaluation by the attending physicians was 67.4%, 79.1% and 48.9% in the Z-30, Z-20 and IN groups, respectively, with a significantly higher efficacy rate for the Z-20 group than for the IN group. The frequency of adverse reactions was 14.3%, 3.9% and 5.6% in the Z-30, Z-20 and IN groups, respectively, with the highest rate in the Z-30 group, but there was no significant difference among the three groups. The useful rate based on total evaluation considering the effective rate and the safety profile in each group was 60.8%, 77.3% and 46.8% in the Z-30, Z-20 and IN groups, respectively, with the highest rate in the Z-20 group showing significant difference from that in the IN group. The above data confirmed the clinical usefulness of Z-100 and suggested that the optimal dose was 20 micrograms twice weekly for Z-100.
AuthorsS Hashimoto, T Ohkawa, Y Takekawa, J Horiuchi, T Mori, S Amino, K Morita, Y Tanaka, Y Mochizuki, T Yanagisawa
JournalNihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica (Nihon Igaku Hoshasen Gakkai Zasshi) Vol. 50 Issue 8 Pg. 977-92 (Aug 25 1990) ISSN: 0048-0428 [Print] Japan
PMID2235345 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, English Abstract, Journal Article, Multicenter Study)
Chemical References
  • Adjuvants, Immunologic
  • Lipids
  • Mannans
  • specific substance maruyama
  • Inosine
Topics
  • Adjuvants, Immunologic (therapeutic use)
  • Aged
  • Double-Blind Method
  • Female
  • Humans
  • Inosine (therapeutic use)
  • Japan
  • Leukopenia (drug therapy, etiology)
  • Lipids (therapeutic use)
  • Male
  • Mannans (therapeutic use)
  • Middle Aged
  • Neoplasms (radiotherapy)
  • Radiotherapy (adverse effects)

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