Abstract |
We have studied the effects of cleistanthin A and cleistanthin B, phytoconstituents isolated from the leaves of Cleistanthus collinus Roxb. (Euphorbiaceae), on blood pressure, electrocardiogram, and barium chloride-induced arrhythmia in Wistar rats. The two compounds were isolated by column chromatography and their identity was confirmed spectroscopically. A healthy, male Wistar rat was used to record the invasive blood pressure and electrocardiograph. The antiarrhythmic effects of cleistanthins A and B were studied using the barium chloride model. Both cleistanthin A and cleistanthin B showed a dose-dependent hypotensive effect. Both compounds reduced the mean blood pressure significantly although the dose required for the effect was higher in the case of cleistanthin B. In the electrocardiogram, cleistanthins A and B significantly altered the electrical activity of the heart, the changes were transient and of no further consequence. Intravenous injection of 64 microg or more of cleistanthins A and B caused a sudden respiratory depression without affecting the electrocardiogram. Cleistanthins A and B did not display any antiarrhythmic effect against barium chloride-induced arrhythmia. In conclusion, both cleistanthin A and cleistanthin B exert a hypotensive effect and have no antiarrhythmic effect against barium chloride-induced arrhythmia in Wistar rats.
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Authors | Subramani Parasuraman, Ramasamy Raveendran, Raja J Selvaraj |
Journal | Zeitschrift fur Naturforschung. C, Journal of biosciences
(Z Naturforsch C J Biosci)
2011 Nov-Dec
Vol. 66
Issue 11-12
Pg. 581-7
ISSN: 0939-5075 [Print] Germany |
PMID | 22351983
(Publication Type: Journal Article)
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Chemical References |
- Glucosides
- Glycosides
- Lignans
- cleistanthin
- cleistanthin B
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Topics |
- Animals
- Blood Pressure
(drug effects)
- Electrocardiography
- Glucosides
(pharmacology)
- Glycosides
(pharmacology)
- Lignans
(pharmacology)
- Male
- Rats
- Rats, Wistar
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