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Potential therapy of multidrug-resistant and extremely drug-resistant tuberculosis with thioridazine.

Abstract
Multidrug-resistant tuberculosis (MDRTB) infections that continue to increase in frequency globally have progressed to become extremely drug-resistant tuberculosis (XDRTB). The therapeutic problems associated with MDRTB pale in comparison to those for XDRTB where mortality is high. This mini-review highlights the evidence that supports the use of the phenothiazine neuroleptic thioridazine for the therapy of XDRTB. Although thioridazine does produce some serious side-effects, the poor prognosis associated with an XDRTB infection of a patient that presents with AIDS merits that the use of thioridazine for therapy of XDRTB is seriously considered. A recommended protocol is presented.
AuthorsLeonard Amaral, Joseph Molnar
JournalIn vivo (Athens, Greece) (In Vivo) 2012 Mar-Apr Vol. 26 Issue 2 Pg. 231-6 ISSN: 1791-7549 [Electronic] Greece
PMID22351663 (Publication Type: Journal Article, Review)
Chemical References
  • Antitubercular Agents
  • Bacterial Proteins
  • Thioridazine
  • Potassium
  • Calcium
Topics
  • AIDS-Related Opportunistic Infections (drug therapy, mortality)
  • Antitubercular Agents (adverse effects, pharmacokinetics, pharmacology, therapeutic use)
  • Bacterial Proteins (antagonists & inhibitors)
  • Biological Availability
  • Calcium (metabolism)
  • Compassionate Use Trials
  • Extensively Drug-Resistant Tuberculosis (drug therapy, mortality)
  • Heart Diseases (chemically induced, prevention & control)
  • Humans
  • Ion Transport (drug effects)
  • Mycobacterium tuberculosis (drug effects)
  • Neuroleptic Malignant Syndrome (etiology, prevention & control)
  • Phagosomes (enzymology, microbiology)
  • Potassium (metabolism)
  • Prognosis
  • Protein Binding (drug effects)
  • Salvage Therapy
  • Thioridazine (adverse effects, pharmacokinetics, pharmacology, therapeutic use)
  • Tuberculosis, Multidrug-Resistant (drug therapy)
  • Tuberculosis, Pulmonary (drug therapy)

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