Role of the hyaluronan-producing tenosynovium in preventing adhesion formation during healing of flexor tendon injuries.

Abstract

Flexor tendons of white Leghorn chickens (n = 25) were used for this study. One chicken was used as a normal control (no surgery), and the remaining 24 were used for experiments. After partial tendon-severing in both legs of 24 chickens, the right and the left leg were treated differently, thereby creating two groups: Group I, in which the tenosynovium was preserved, and Group II, in which the tenosynovium was removed. Hematoxylin-eosin staining was performed to observe adhesions; immunohistochemical analysis was used to localize HA. HA production was noted in granulation tissue invading between the tendon stumps in both groups; however, HA expression in the tenosynovium was observed only in Group I where adhesion formation was minimal. The HA-producing tenosynovium plays a crucial role in preventing adhesion formation in this model of flexor tendon injuries.

• Authors: Masaharu Yagi, Yasuhiro Mitsui, Masafumi Gotoh, Naoto Sato, Kenji Yoshida, Kensei Nagata
• Journal: Hand surgery : an international journal devoted to hand and upper limb surgery and related research : journal of the Asia-Pacific Federation of Societies for Surgery of the Hand (Hand Surg) Vol. 17 Issue 1 Pg. 13-7 ( 2012) ISSN: 1793-6535 [Electronic] Singapore
• PMID: 22351527 (Publication Type: Journal Article)

Chemical References

• Hyaluronan Receptors
• Hyaluronic Acid

Topics

• Animals
• Chickens
• Disease Models, Animal
• Granulation Tissue (metabolism)
• Humans
• Hyaluronan Receptors (metabolism)
• Hyaluronic Acid (metabolism)
• Immunohistochemistry
• Synovial Membrane (metabolism)
• Tendon Injuries (metabolism, pathology, surgery)
• Tissue Adhesions (prevention & control)
• Wound Healing