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In vitro system for studying the efficacy of antiviral agents in preventing the reactivation of latent herpes simplex virus.

Abstract
Antiviral antibody and interferon did not prevent in vitro reactivation of herpes simplex virus in latently infected sensory ganglia. Phosphonoacetic acid and 9-beta-d-arabinofuranosyladenine blocked reactivation, but this treatment did not eradicate the latent infection.
AuthorsC Wohlenberg, H Openshaw, A L Notkins
JournalAntimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 15 Issue 4 Pg. 625-7 (Apr 1979) ISSN: 0066-4804 [Print] United States
PMID223499 (Publication Type: Journal Article)
Chemical References
  • Antibodies, Viral
  • Antiviral Agents
  • Interferons
  • Vidarabine
  • Phosphonoacetic Acid
Topics
  • Animals
  • Antibodies, Viral
  • Antiviral Agents (pharmacology)
  • Female
  • Ganglia (microbiology)
  • Herpes Simplex (immunology, microbiology)
  • Interferons (pharmacology)
  • Mice
  • Mice, Inbred BALB C
  • Phosphonoacetic Acid (pharmacology)
  • Simplexvirus (drug effects)
  • Vidarabine (pharmacology)

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