Effective protection induced by three different versions of the porcine S3Pvac anticysticercosis vaccine against rabbit experimental Taenia pisiformis cysticercosis.

Abstract

In an effort to develop an effective and affordable oral vaccine against porcine Taenia solium cysticercosis, the S3Pvac anti-cysticercosis vaccine was expressed in papaya calli. Taenia pisiformis experimental rabbit cysticercosis was used as a model to compare the efficacy of the oral vaccine vs. the injectable S3Pvac-synthetic and S3Pvac-phage versions. Oral S3Pvac-papaya significantly reduced the expected number of hepatic lesions and peritoneal cysticerci to a similar extent than the injectable vaccines. This study reports for the first time an effective oral vaccine against T. pisiformis cysticercosis, possibly useful against porcine T. solium cysticercosis.

• Authors: Miguel Angel Betancourt, Aline S de Aluja, Edda Sciutto, Marisela Hernández, Raúl J Bobes, Gabriela Rosas, Beatriz Hernández, Gladis Fragoso, Claudia Hallal-Calleros, Liliana Aguilar, Iván Flores-Peréz
• Journal: Vaccine (Vaccine) Vol. 30 Issue 17 Pg. 2760-7 (Apr 05 2012) ISSN: 1873-2518 [Electronic] Netherlands
• PMID: 22349522 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Insect Proteins
• Protozoan Vaccines
• NADH Dehydrogenase

Topics

• Animals
• Base Sequence
• Cysticercosis (pathology, prevention & control)
• Cysticercus (immunology)
• Female
• Inflammation (immunology, pathology)
• Insect Proteins (genetics)
• Liver (immunology, pathology)
• Molecular Sequence Data
• NADH Dehydrogenase (genetics)
• Peritoneal Cavity (parasitology, pathology)
• Protozoan Vaccines (administration & dosage, immunology)
• Rabbits
• Sequence Alignment
• Taenia (genetics, immunology)