HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Alcaftadine: a topical antihistamine for use in allergic conjunctivitis.

Abstract
Alcaftadine (Lastacaft®; Allergen, Inc.) is a broad-spectrum antihistamine displaying a high affinity for histamine H1 and H2 receptors and a lower affinity for H4 receptors. It also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects. The authors reviewed all available English-language literature characterizing the efficacy, safety and pharmacokinetic profile of alcaftadine ophthalmic solution. In the studies reviewed, alcaftadine was more effective than placebo and at least as effective as olopatadine 0.01% in preventing ocular itching at 15 minutes and at 16 hours after administration. Alcaftadine 0.025% ophthalmic solution has been approved by the U.S. Food and Drug Administration for prevention of itching associated with allergic conjunctivitis in patients over 2 years of age. Comparative efficacy data of alcaftadine to other ocular antihistamine/mast cell stabilizers are limited.
AuthorsR Namdar, C Valdez
JournalDrugs of today (Barcelona, Spain : 1998) (Drugs Today (Barc)) Vol. 47 Issue 12 Pg. 883-90 (Dec 2011) ISSN: 1699-3993 [Print] United States
PMID22348913 (Publication Type: Journal Article, Review)
Chemical References
  • Benzazepines
  • HRH4 protein, human
  • Imidazoles
  • Ophthalmic Solutions
  • Receptors, G-Protein-Coupled
  • Receptors, Histamine
  • alcaftadine
Topics
  • Administration, Topical
  • Animals
  • Benzazepines (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
  • Conjunctivitis, Allergic (drug therapy)
  • Drug Interactions
  • Humans
  • Imidazoles (administration & dosage, adverse effects, pharmacokinetics, therapeutic use)
  • Ophthalmic Solutions
  • Pruritus (drug therapy)
  • Randomized Controlled Trials as Topic
  • Receptors, G-Protein-Coupled (drug effects)
  • Receptors, Histamine (drug effects)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: