Abstract | INTRODUCTION: OBJECTIVE: This study evaluated the effectiveness and patient satisfaction of oral oxybutynin at low doses (5 mg twice daily) compared with placebo for treating palmar hyperhidrosis. METHODS: This was prospective, randomized, and controlled study. From December 2010 to February 2011, 50 consecutive patients with palmar hyperhidrosis were treated with oxybutynin or placebo. Data were collected from 50 patients, but 5 (10.0%) were lost to follow-up. During the first week, patients received 2.5 mg of oxybutynin once daily in the evening. From days 8 to 21, they received 2.5 mg twice daily, and from day 22 to the end of week 6, they received 5 mg twice daily. All patients underwent two evaluations, before and after (6 weeks) the oxybutynin treatment, using a clinical questionnaire and a clinical protocol for quality of life. RESULTS: Palmar and axillary hyperhidrosis improved in >70% of the patients, and 47.8% of those presented great improvement. Plantar hyperhidrosis improved in >90% of the patients. Most patients (65.2%) showed improvements in their quality of life. The side effects were minor, with dry mouth being the most frequent (47.8%). CONCLUSIONS: Treatment of palmar and axillary hyperhidrosis with oxybutynin is a good initial alternative for treatment given that it presents good results and improves quality of life.
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Authors | Nelson Wolosker, José Ribas Milanez de Campos, Paulo Kauffman, Pedro Puech-Leão |
Journal | Journal of vascular surgery
(J Vasc Surg)
Vol. 55
Issue 6
Pg. 1696-700
(Jun 2012)
ISSN: 1097-6809 [Electronic] United States |
PMID | 22341836
(Publication Type: Journal Article, Randomized Controlled Trial)
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Copyright | Copyright © 2012 Society for Vascular Surgery. Published by Mosby, Inc. All rights reserved. |
Chemical References |
- Mandelic Acids
- Muscarinic Antagonists
- oxybutynin
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Topics |
- Adolescent
- Adult
- Brazil
- Chi-Square Distribution
- Drug Administration Schedule
- Female
- Humans
- Hyperhidrosis
(drug therapy, physiopathology, psychology)
- Male
- Mandelic Acids
(administration & dosage, adverse effects)
- Middle Aged
- Muscarinic Antagonists
(administration & dosage, adverse effects)
- Patient Satisfaction
- Prospective Studies
- Quality of Life
- Surveys and Questionnaires
- Sweating
(drug effects)
- Time Factors
- Treatment Outcome
- Young Adult
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