Abstract | OBJECTIVE: To explore the expression and significance of secretions of hypothalamus-pituitary-adrenal (HPA) axis in human hypertrophic scar. METHODS: RESULTS: The mRNA expression of CRH, CRH-R1, POMC, and GR-α in hypertrophic scar was respectively 3.1 ± 0.8, 0.05 ± 0.03, 0.020 ± 0.007, and 0.0030 ± 0.0010, which were significantly lower than those in normal skin (20.6 ± 4.7, 0.30 ± 0.12, 0.060 ± 0.020, and 0.0200 ± 0.0070, with t values from 2.10 to 4.75, P values all below 0.05). There was no statistical difference in MC-2R mRNA expression between hypertrophic scar and normal skin (t = 1.48, P = 0.15). Immunohistochemical observation showed CRH, CRH-R1, ACTH, MC-2R, and GR-α in hypertrophic scar were located in basal layer of epidermis, fibroblast of dermis, and tube wall of sweat gland. Expressions of these indexes could also be observed in sebaceous gland and hair follicle besides above-mentioned structures. CONCLUSIONS: Decreasing expression of active material of HPA axis may be related to formation of hypertrophic scar.
|
Authors | Si-jun Liu, You-fu Xie, Li-bing Dai, Gao-wei Du |
Journal | Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns
(Zhonghua Shao Shang Za Zhi)
Vol. 27
Issue 6
Pg. 432-5
(Dec 2011)
ISSN: 1009-2587 [Print] China |
PMID | 22340789
(Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Glucocorticoids
- Adrenocorticotropic Hormone
|
Topics |
- Adolescent
- Adrenocorticotropic Hormone
(metabolism)
- Adult
- Child
- Cicatrix, Hypertrophic
(metabolism)
- Female
- Glucocorticoids
(metabolism)
- Humans
- Hypothalamo-Hypophyseal System
(metabolism)
- Male
- Pituitary-Adrenal System
(metabolism)
- Young Adult
|