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Glycine decarboxylase cleaves a "malignant" metabolic path to promote tumor initiation.

Abstract
Tumor-initiating cells (TICs) are thought to be critical for promoting tumorigenesis. In a recent Cell article, Zhang and colleagues found that non-small cell lung cancer TICs overexpress the metabolic enzyme glycine decarboxylase, which leads to increases in pyrimidine synthesis and is critical for proliferation and tumor initiation.
AuthorsJohn E Dominy, Francisca Vazquez, Pere Puigserver
JournalCancer cell (Cancer Cell) Vol. 21 Issue 2 Pg. 143-5 (Feb 14 2012) ISSN: 1878-3686 [Electronic] United States
PMID22340586 (Publication Type: Comment, Journal Article)
CopyrightCopyright © 2012 Elsevier Inc. All rights reserved.

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