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Protective effect of morin on cardiac mitochondrial function during isoproterenol-induced myocardial infarction in male Wistar rats.

Abstract
Altered mitochondrial function and free radical-mediated tissue damage have been suggested as an important pathological event in isoproterenol (ISO)-induced cardiotoxicity. This study was undertaken to know the preventive effect of morin on mitochondrial damage in ISO-induced cardiotoxicity in male Wistar rats. Myocardial infarction (MI) in rats was induced by ISO (85 mg/kg) at an interval of 24 hours for 2 days. Morin was given to rats as pre-treatment for 30 days orally using an intragastric tube. ISO-treated rats showed a significant elevation of mitochondrial thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (HP) level and pre-treatment with morin significantly prevented the increase of TBARS and HP level to near normality. The level of enzymic and non-enzymic antioxidants was decreased significantly in ISO-treated rats and pre-treatment with morin significantly increased the levels of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase, and reduced glutathione to normality. The activities of mitochondrial enzymes such as isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase were decreased significantly in ISO-treated myocardial ischemic rats and upon pre-treatment with morin restored these enzymes activity to normality. In addition, the decreased activities of cytochrome-C oxidase and NADH-dehydrogenases were observed in ISO-treated rats and pre-treatment with morin prevented the activities of cytochrome-C oxidase and NADH-dehydrogenase to normality. Pre-treatment with morin favorably restored the biochemical and functional parameters to near normal indicating morin to be a significant protective effect on cardiac mitochondrial function against ISO-induced MI in rats.
AuthorsKhalid S Al Numair, Govindasamy Chandramohan, Mohammed A Alsaif, Arul Albert Baskar
JournalRedox report : communications in free radical research (Redox Rep) Vol. 17 Issue 1 Pg. 14-21 ( 2012) ISSN: 1743-2928 [Electronic] England
PMID22340511 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References
  • Antioxidants
  • Flavonoids
  • Lipid Peroxides
  • Mitochondrial Proteins
  • Thiobarbituric Acid Reactive Substances
  • morin
  • Hydrogen Peroxide
  • NADH Dehydrogenase
  • Electron Transport Complex IV
  • Isoproterenol
Topics
  • Animals
  • Antioxidants (metabolism)
  • Cell Membrane (metabolism)
  • Electron Transport Complex IV (metabolism)
  • Enzyme Activation
  • Flavonoids (therapeutic use)
  • Hydrogen Peroxide (metabolism)
  • Isoproterenol (adverse effects)
  • Lipid Peroxides (metabolism)
  • Male
  • Mitochondria, Heart (drug effects, enzymology)
  • Mitochondrial Proteins (metabolism)
  • Myocardial Infarction (chemically induced, drug therapy, metabolism)
  • NADH Dehydrogenase (metabolism)
  • Rats
  • Rats, Wistar
  • Thiobarbituric Acid Reactive Substances (metabolism)

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