Dietary D-psicose reduced visceral fat mass in high-fat diet-induced obese rats.

Abstract

UNLABELLED:

D-Psicose, a C-3 epimer of D-fructose, has shown promise in reducing body fat accumulation in normal rats and plasma glucose level in genetic diabetic mice. Effects of D-psicose on diet-induced obesity are not clearly elucidated, and we investigated food intake, body weight, and fat accumulation in rats fed high-fat (HF) diet. Sprague-Dawley rats became obese by feeding HF diet for 4 wk, and were assigned either to normal or HF diet supplemented with or without D-psicose, sucrose, or erythritol for 8 wk. Changing HF to normal diet gained less body weight and adipose tissue due to different energy intake. D-psicose-fed rats exhibited lower weight gain, food efficiency ratio, and fat accumulation than erythritol- and sucrose-fed rats. This effect was more prominent in D-psicose-fed rats with normal diet than with HF diet, suggesting combination of psicose and calorie restriction further reduced obesity. There was no difference in serum cholesterol/high-density lipoprotein (HDL)-C and low-density lipoprotein (LDL)-C/HDL-C ratios between D-psicose group and other groups. Liver weight in 5% psicose group with normal diet was higher than in other groups, but histopathological examination did not reveal any psicose-related change. D-Psicose inhibited the differentiation of mesenchymal stem cell (MSC) to adipose tissue in a concentration-dependent manner. These results demonstrate that D-psicose produces a marked decrease, greater than erythritol, in weight gain and visceral fat in an established obesity model by inhibiting MSC differentiation to adipocyte. Thus, D-psicose can be useful in preventing and reducing obesity as a sugar substitute and food ingredient.

PRACTICAL APPLICATION:

We can develop D-psicose as a sugar substitute and food ingredient since it can prevent obesity in normal people, but also suppress adiposity as a sugar substitute or food ingredients with antiobesity effect in obese people. D-psicose can be unique functional sweetener because of its function of reducing visceral fat mass and weight gain.

• Authors: Young-Mee Chung, Joo Hyun Lee, Deuk Youl Kim, Se-Hee Hwang, Young-Ho Hong, Seong-Bo Kim, Song Jin Lee, Chi Hye Park
• Journal: Journal of food science (J Food Sci) Vol. 77 Issue 2 Pg. H53-8 (Feb 2012) ISSN: 1750-3841 [Electronic] United States
• PMID: 22339545 (Publication Type: Journal Article)
• Copyright: © 2012 Institute of Food Technologists®

Chemical References

• Lipoproteins, HDL
• Lipoproteins, LDL
• psicose
• Fructose

Topics

• Adipocytes (drug effects)
• Animals
• Body Composition (drug effects)
• Body Weight (drug effects)
• Diet, High-Fat (adverse effects)
• Dietary Supplements
• Energy Intake (drug effects)
• Fructose (administration & dosage)
• Intra-Abdominal Fat (drug effects)
• Lipoproteins, HDL (blood)
• Lipoproteins, LDL (blood)
• Male
• Obesity (diet therapy, etiology)
• Rats
• Rats, Sprague-Dawley