[Comparative effects of low and medium molecular hydroxyethyl starch (HES) solutions on hemorrhagic shock in rats].

Abstract

BACKGROUND:

Hydroxyethyl starch (HES) solutions are frequently used plasma expanders. We examined the effects of medium-HES (mean molecular weight of 130,000 dalton) and low-HES (mean molecular weight of 70,000 dalton) on the survival rates (Exp. I), colloid osmotic pressure (COP) (Exp. II) and coagulation (Exp. III) with rats in hemorrhagic shock.

METHODS:

Hemorrhagic shock was induced by removing 55% (Exp. I) and 20% (Exp. II and III) of the circulating blood volume. Saline, low-HES or medium-HES of the same volume with the removed blood was intravenously infused immediately after bleeding.

RESULTS:

Exp. I: In survival rate, effect of medium-HES was significantly superior to that of saline. Exp. II: The COP of medium-HES group was significantly higher than that of saline group 3 hrs after hemorrhagic shock. Exp. III: There were no changes in von Willerbrand factor and factor VIII 3 hrs after hemorrhagic shock among saline, low-HES and medium-HES.

CONCLUSIONS:

Medium-HES and low-HES are efficacious plasma volume substitutes; however, the ability of medium-HES to prolong maintenance of COP better than low-HES is a finding that would be significant in a clinical setting involving preoperative blood management and extreme blood loss.

• Authors: Maki Yoneko, Yasuyuki Suzuki, Jun Kojima
• Journal: Masui. The Japanese journal of anesthesiology (Masui) Vol. 61 Issue 1 Pg. 57-63 (Jan 2012) ISSN: 0021-4892 [Print] Japan
• PMID: 22338861 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Hydroxyethyl Starch Derivatives
• Plasma Substitutes
• Solutions

Topics

• Animals
• Blood Coagulation (drug effects)
• Disease Models, Animal
• Hydroxyethyl Starch Derivatives (therapeutic use)
• Male
• Molecular Weight
• Osmotic Pressure (drug effects)
• Plasma Substitutes (therapeutic use)
• Rats
• Rats, Sprague-Dawley
• Shock, Hemorrhagic (blood, drug therapy, mortality)
• Solutions
• Survival Rate