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Phenazines and cancer.

Abstract
Phenazines are a large group of natural and synthesised nitrogen-containing heterocycles, including more than 100 different compounds of natural origin and over 6000 synthetic compounds. Many of these compounds have been investigated as potential anti-cancer agents. Despite a large number of research publications, no recent attempt to summarise and critically evaluate the experimental findings relating to the anti-cancer activity of this class of compounds has been made. The present review fills this gap in the literature and discusses both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti-cancer activities of these compounds.
AuthorsA Cimmino, A Evidente, V Mathieu, A Andolfi, F Lefranc, A Kornienko, R Kiss
JournalNatural product reports (Nat Prod Rep) Vol. 29 Issue 4 Pg. 487-501 (Apr 2012) ISSN: 1460-4752 [Electronic] England
PMID22337153 (Publication Type: Journal Article, Review)
Chemical References
  • Antineoplastic Agents
  • Phenazines
Topics
  • Antineoplastic Agents (chemical synthesis, chemistry, isolation & purification, pharmacology)
  • Humans
  • Molecular Structure
  • Phenazines (chemical synthesis, chemistry, isolation & purification, pharmacology)

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