Abstract |
Phenazines are a large group of natural and synthesised nitrogen-containing heterocycles, including more than 100 different compounds of natural origin and over 6000 synthetic compounds. Many of these compounds have been investigated as potential anti- cancer agents. Despite a large number of research publications, no recent attempt to summarise and critically evaluate the experimental findings relating to the anti- cancer activity of this class of compounds has been made. The present review fills this gap in the literature and discusses both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti- cancer activities of these compounds.
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Authors | A Cimmino, A Evidente, V Mathieu, A Andolfi, F Lefranc, A Kornienko, R Kiss |
Journal | Natural product reports
(Nat Prod Rep)
Vol. 29
Issue 4
Pg. 487-501
(Apr 2012)
ISSN: 1460-4752 [Electronic] England |
PMID | 22337153
(Publication Type: Journal Article, Review)
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Chemical References |
- Antineoplastic Agents
- Phenazines
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Topics |
- Antineoplastic Agents
(chemical synthesis, chemistry, isolation & purification, pharmacology)
- Humans
- Molecular Structure
- Phenazines
(chemical synthesis, chemistry, isolation & purification, pharmacology)
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