Effects of steroid with repetitive procaine HCl injection in the management of carpal tunnel syndrome: an ultrasonographic study.

Abstract

BACKGROUND AND AIM:

With the use of musculoskeletal ultrasonography (MSUS), morphological changes in the median nerve have been recently reported in patients with carpal tunnel syndrome (CTS). On the other hand, the literature still lacks the information whether those changes are further altered with steroid and local anesthetic injection which is a widely used treatment in this group of patients. Therefore, the aim of our study was to explore in-vivo the effects of steroid with repetitive procaine HCl injection on the median nerve of patients with CTS.

MATERIALS AND METHOD:

This prospective clinical trial followed-up patients for 2 months. 22 patients (37 median nerves) with clinical and electrophysiological evidence of CTS were included in the study. All patients received both 40 mg of triamcinolone acetonide once and 4 ml of 1% procaine HCl twice a week for 2 weeks with the same technique. Clinical, functional, electrophysiological and ultrasonographic evaluations were performed at the study onset, and 2 months after the last injection.

RESULTS:

Electrophysiological, ultrasonographic findings (median nerve anterior-posterior diameter, transverse diameter and cross sectional area in the proximal carpal tunnel and volar bulging,) VAS scores, Boston carpal tunnel symptom and function assessment scale improved significantly (P<0.05).

CONCLUSION:

Steroid injection with repetitive procaine HCl injection effectively reduced the symptoms of CTS, improved the Boston carpal tunnel symptom and function assessment scale and also electrophysiological and ultrasonographic findings. Long term effects remain to be studied. Indisputably, the use of MSUS seems to be promising in this regard.

• Authors: Omer Karadaş, Ozlem Köroğlu Omaç, Fatih Tok, Ahmet Ozgül, Zeki Odabaşi
• Journal: Journal of the neurological sciences (J Neurol Sci) Vol. 316 Issue 1-2 Pg. 76-8 (May 15 2012) ISSN: 1878-5883 [Electronic] Netherlands
• PMID: 22336701 (Publication Type: Clinical Trial, Comparative Study, Journal Article)
• Copyright: Copyright © 2012 Elsevier B.V. All rights reserved.

Chemical References

• Anti-Inflammatory Agents
• Anti-Inflammatory Agents, Non-Steroidal
• Procaine
• Triamcinolone Acetonide

Topics

• Adult
• Aged
• Anti-Inflammatory Agents (administration & dosage)
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Carpal Tunnel Syndrome (diagnostic imaging, drug therapy)
• Disease Management
• Drug Administration Schedule
• Drug Therapy, Combination
• Female
• Follow-Up Studies
• Humans
• Male
• Middle Aged
• Procaine (administration & dosage)
• Prospective Studies
• Treatment Outcome
• Triamcinolone Acetonide (administration & dosage)
• Ultrasonography