Influence of matrix metalloproteinase synthetic inhibitors on dentin microtensile bond strength of resin cements.

Abstract

This study evaluated the effect of dentin pretreatment with 2% chlorhexidine (CHX) or 24% ethylenediamine tetra-acetic acid gel (EDTA) on the dentin microtensile bond strength (μTBS) of resin cements. Composite blocks were luted to superficial noncarious human dentin (n=10) using two resin cements (RelyX ARC [ARC] and RelyX U100 [U100]) and three dentin pretreatments (without pretreatment-control, CHX, and EDTA). CHX was applied for 60 seconds on the acid-etched dentin in the ARC/CHX group, and for the same time on smear layer-covered dentin in the U100/CHX group. EDTA was applied for 45 seconds on smear-covered dentin in the U100/EDTA group, and it replaced phosphoric acid conditioning in the ARC/EDTA group for 60 seconds. After storage in water for 24 hours, specimens were prepared for microtensile bond strength testing. The results were submitted to two-way analysis of variance (ANOVA) followed by Tukey test. ARC produced significantly higher μTBS (p<0.05) compared to the U100, except when EDTA was used. For ARC, no pretreatment and CHX produced higher μTBS than EDTA. For U100, EDTA produced higher μTBS; no statistical difference occurred between CHX pretreatment and when no pretreatment was performed. While CHX did not affect immediate dentin bond strength of both cements, EDTA improved bond strength of U100, but it reduced dentin bond strength of ARC.

• Authors: T H S Stape, M S Menezes, B C F Barreto, F H B Aguiar, L R Martins, P S Quagliatto
• Journal: Operative dentistry (Oper Dent) 2012 Jul-Aug Vol. 37 Issue 4 Pg. 386-96 ISSN: 0361-7734 [Print] United States
• PMID: 22335305 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)

Chemical References

• Composite Resins
• Matrix Metalloproteinase Inhibitors
• Methacrylates
• Polymethacrylic Acids
• RelyX ARC
• Resin Cements
• filtek Z350
• Water
• Polyethylene Glycols
• Bisphenol A-Glycidyl Methacrylate
• Edetic Acid
• Chlorhexidine

Topics

• Acid Etching, Dental (methods)
• Bisphenol A-Glycidyl Methacrylate (chemistry)
• Chlorhexidine (chemistry)
• Composite Resins (chemistry)
• Dental Bonding
• Dental Stress Analysis (instrumentation)
• Dentin (ultrastructure)
• Edetic Acid (chemistry)
• Humans
• Materials Testing
• Matrix Metalloproteinase Inhibitors
• Methacrylates (chemistry)
• Microscopy, Electron, Scanning
• Polyethylene Glycols (chemistry)
• Polymethacrylic Acids (chemistry)
• Resin Cements (chemistry)
• Smear Layer
• Stress, Mechanical
• Surface Properties
• Tensile Strength
• Time Factors
• Water (chemistry)