Abstract |
The association of estradiol valerate/dienogest (E2V/DNG) is an innovative contraceptive choice with relevant consequences for quality of life of women at all ages. Klaira® (E2V/DNG) combines the use of natural estradiol in a dynamic dosing regimen with a progestin very similar to natural progesterone but with very potent antiproliferative action at the endometrial level. The high contraceptive efficacy of E2V/DNG is associated with a good menstrual cycle control which leads to a novel therapeutic indication in heavy menstrual bleeding. The mild hemostatic and metabolic impact is highly important for women over 35 years, especially when painful syndromes are present ( dysmenorrhea and headache), with potential benefits of E2V/DNG, even though the current contraindications of hormonal contraception with ethynilestradiol are still present. In addition, good tolerability and the evidence of beneficial effects on sexual function make E2V/DNG a contraceptive hormonal method with a favourable profile in term of psychophysical well being of women.
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Authors | R E Nappi |
Journal | Minerva ginecologica
(Minerva Ginecol)
Vol. 64
Issue 1
Pg. 41-52
(Feb 2012)
ISSN: 0026-4784 [Print] Italy |
Vernacular Title | La scelta contraccettiva a base di E2V/DNG per una migliore qualità di vita delle donne. |
PMID | 22334230
(Publication Type: Journal Article, Review)
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Chemical References |
- Contraceptive Agents
- Contraceptives, Oral, Combined
- dienogest
- Estradiol
- Nandrolone
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Topics |
- Contraceptive Agents
(therapeutic use)
- Contraceptives, Oral, Combined
(therapeutic use)
- Estradiol
(analogs & derivatives, therapeutic use)
- Female
- Humans
- Nandrolone
(analogs & derivatives, therapeutic use)
- Quality of Life
- Sexuality
(drug effects)
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