[Effects of aprepitant in daily administrations of low-dose cisplatin].

Abstract

OBJECTIVE:

While aprepitant is actually recommended for the prevention of nausea and vomiting induced by a single cisplatin administration, it is still unclear whether it has a clinical benefit when administered along with daily administrations of low- dose cisplatin(20mg/m2 days 1-5). This study was conducted to evaluate the efficacy of aprepitant in patients receiving daily administration of low-dose cisplatin.

METHODS:

Our study focused on 25 patients who received cancer therapy including cisplatin, with or without aprepitant (days 1-5). We performed a retrospective study to identify any significant positive effect of aprepitant in the prevention of nausea and vomiting for 10 days(days 1-10). Because cisplatin has a long half-life, we assessed the delayed phase nausea and vomiting(days 6-10).

RESULTS AND CONCLUSION:

Multiple-day dosing of aprepitant was effective for prevention of nausea(Odds ratio: 0. 30, p= 0. 0012)and vomiting(Odds ratio: 0. 04, p=0. 0001)throughout the observation. Furthermore, we observed a significant positive effect of aprepitant in the prevention of delayed nausea(Odds ratio: 0. 19, p=0. 0083)and vomiting(Odds ratio: 0. 07, p=0. 0040). These findings suggest that multiple-day dosing of aprepitant is useful for the inhibition of acute delayed nausea and vomiting caused by chemotherapy including daily administration of low-dose cisplatin.

• Authors: Misato Kariya, Kenta Tanaka, Kumiko Matsumoto, Manabu Kume, Hiroo Makimoto, Takeshi Hirano, Hideaki Miyake, Masato Fujisawa, Midori Hirai
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 39 Issue 2 Pg. 245-50 (Feb 2012) ISSN: 0385-0684 [Print] Japan
• PMID: 22333636 (Publication Type: Journal Article)

Chemical References

• Morpholines
• Aprepitant
• Cisplatin

Topics

• Adult
• Aprepitant
• Cisplatin (administration & dosage, adverse effects)
• Female
• Humans
• Male
• Morpholines (administration & dosage, therapeutic use)
• Nausea (chemically induced, prevention & control)
• Retrospective Studies
• Vomiting (chemically induced, prevention & control)