[Assessment of nausea and vomiting during FEC regimen for breast cancer after the novel antiemetic agent - introduction using MASCC antiemesis tool].

Abstract

Chemotherapy-induced nausea and vomiting(CINV)is one of the side effects causing significant psychological and physical suffering in patients receiving chemotherapy. Because CINV often impairs patients' quality of life and leads to discontinuation of treatments, antiemetic therapy has been considered important. The MASCC Antiemesis Tool(MAT)was proposed for the assessment of acute and delayed nausea and vomiting after, we evaluated the actual situation of nausea and vomiting for Japanese patients. In a previous investigation, even conventional antiemesis therapy was a highly effective treatment during the acute phase, but the control of nausea and vomiting during the delayed phase proved difficult. Recently, a new5 -HT3 receptor blocker(palonosetron)and an NK1 receptor blocker(aprepitant) were introduced, and an effective treatment of nausea and vomiting for the delayed phase is non expected. In this examination, we evaluated the usefulness of the new antiemetic drugs(palonosetron and aprepitant)in 12 prospective patients with breast cancer(40-69 years old, median age 53 years old)for whom FEC therapy was given as an ambulant treatment using MAT. No vomiting occurred in the acute and delayed phase. Nausea during the acute phase was controlled, and was mild during the delayed phase, also. It was confirmed that the onset of acute and delayed nausea and vomiting were relieved by the newantiemetic agents compared with the previous MAT evaluation.

• Authors: Chiya Oshiro, Shunji Kamigaki, Yukio Nakamura, Takashi Arai, Yukie Kanai, Misako Fujino, Chika Fujii, Yoshiko Hamaguchi, Chihiro Iseki, Yoshimi Hachino, Hiroshi Furukawa
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 39 Issue 2 Pg. 241-4 (Feb 2012) ISSN: 0385-0684 [Print] Japan
• PMID: 22333635 (Publication Type: English Abstract, Journal Article)

Chemical References

• Antiemetics
• Epirubicin
• Cyclophosphamide
• Fluorouracil

Topics

• Adult
• Aged
• Antiemetics (therapeutic use)
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Breast Neoplasms (drug therapy)
• Cyclophosphamide (adverse effects, therapeutic use)
• Epirubicin (adverse effects, therapeutic use)
• Female
• Fluorouracil (adverse effects, therapeutic use)
• Humans
• Middle Aged
• Nausea (chemically induced, prevention & control)
• Vomiting (chemically induced, prevention & control)