Abstract | BACKGROUND: METHODS AND RESULTS: Susceptibility to ventricular fibrillation (VF) was evaluated using a 2-minute left circumflex artery occlusion during the last minute of an exercise test in 76 dogs (from 2 independent studies) with healed myocardial infarctions (MI); 44 developed VF (susceptible, VF+), whereas 32 did not (resistant, VF-). These dogs were then randomly assigned to either placebo (1 g/d, corn oil; 15 VF+, 11 VF-) or n-3 PUFA (1-4 g/d, docosahexaenoic acid+eicosapentaenoic acid ethyl esters, 29 VF+, 21 VF-) groups. Seven sham (no-MI) dogs were also treated with n-3 PUFA (4 g/d). After treatment (3 months), the exercise+ischemia test was repeated. Dietary n-3 PUFAs produced significant (P<0.01) increases in red blood cell and left ventricular n-3 PUFA levels. Nine post-MI (5 placebo versus 4 n-3 PUFA) and 2 sham dogs died suddenly during the 3-month treatment period. The n-3 PUFA treatment failed to prevent arrhythmias in VF+ dogs (decreased in 27% placebo versus 24% n-3 PUFA, P=0.5646) but induced VT/VF in VF- animals ( n-3 PUFA 33% versus placebo 0%, P=0.0442). CONCLUSIONS: Despite large increases in cardiac tissue n-3 PUFA content, dietary n-3 PUFAs did not prevent ischemia-induced VF and actually increased arrhythmia susceptibility in both noninfarcted and low-risk post-MI dogs.
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Authors | George E Billman, Cynthia A Carnes, Philip B Adamson, Emilio Vanoli, Peter J Schwartz |
Journal | Circulation. Arrhythmia and electrophysiology
(Circ Arrhythm Electrophysiol)
Vol. 5
Issue 3
Pg. 553-60
(Jun 01 2012)
ISSN: 1941-3084 [Electronic] United States |
PMID | 22333345
(Publication Type: Comparative Study, Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Animals
- Death, Sudden, Cardiac
(etiology, prevention & control)
- Disease Models, Animal
- Disease Susceptibility
- Dogs
- Dose-Response Relationship, Drug
- Electrocardiography
- Fatty Acids, Omega-3
(administration & dosage)
- Female
- Male
- Physical Conditioning, Animal
- Prognosis
- Treatment Failure
- Ventricular Fibrillation
(complications, diet therapy, physiopathology)
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