[Study on protective effect of Tianji soft capsule on blood lipids, internal antioxidant system and vascular endothelial system in hyperlipidemia rats].

Abstract

OBJECTIVE:

To study the protective effects of Tianji soft capsule (TJSC) on blood lipids, internal antioxidant system and vascular endothelial system in hyperlipidemia rats.

METHODS:

Seventy two healthy male rats were divided into six groups. The rats in control group were administered with ordinary diet. The rats in model group were fed with high cholesterol/lipid diet to induce hyperlipidemia. The rats in TJSC and CoQ10 groups were fed with high cholesterol/lipid diet, and treated with TJSC at different doses of 83 (low-dose group, L), 250 (middle-dose group, M), 750 (high-dose group, H) mg/kg, and CoQ10 at the dose of 83 mg/kg, respectively. All animals were put to death after four weeks, effects on lipid level; antioxidant system and endothelial system were evaluated through detection of total cholesterol (TC), triglyceride (TG), very low density lipoprotein (VLDL), atherogenic index (AI), malondidehyde (MDA) and plasma endothelin (ET), HDL/TC ratio, activities of superoxide dismutase (SOD) and nitric oxide (NO).

RESULTS:

Compared with model group, serum TC, TG, VLDL, AI, MDA and ET reduced and the HDL/TC ratio increased, meanwhile activities of SOD and NO were enhanced.

CONCLUSION:

TJSC can regulate the lipid metabolism, enhance antioxidant system and protect the vascular endothelia system in hyperlipiemic rats.

• Authors: Hai-ying Ma, Jin-yao Chen, Li-shi Zhang
• Journal: Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition (Sichuan Da Xue Xue Bao Yi Xue Ban) Vol. 42 Issue 6 Pg. 780-3 (Nov 2011) ISSN: 1672-173X [Print] China
• PMID: 22332541 (Publication Type: English Abstract, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Dietary Fats
• Drugs, Chinese Herbal
• Endothelins
• Lipids
• Superoxide Dismutase

Topics

• Animals
• Dietary Fats (administration & dosage)
• Drug Compounding
• Drugs, Chinese Herbal (pharmacology, therapeutic use)
• Endothelins (metabolism)
• Endothelium, Vascular (metabolism)
• Hippophae (chemistry)
• Hyperlipidemias (blood, metabolism, prevention & control)
• Lipids (blood)
• Male
• Random Allocation
• Rats
• Rats, Sprague-Dawley
• Rhodiola (chemistry)
• Superoxide Dismutase (metabolism)